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. 2024 Oct 17;16(4):636-647.
doi: 10.3390/hematolrep16040062.

Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia: Results of a Single-Center Study

Davide Stella  1   2 , Jessica Gill  1   2 , Roberto Passera  3 , Sofia Zompi  2 , Chiara Maria Dellacasa  2 , Ernesta Audisio  4 , Marco Cerrano  4 , Irene Dogliotti  2 , Michele Dicataldo  2 , Carolina Secreto  2 , Benedetto Bruno  1   2 , Roberto Freilone  4 , Alessandro Busca  2 , Luisa Giaccone  1   2
Affiliations

Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia: Results of a Single-Center Study

Davide Stella et al. Hematol Rep. .

Abstract

Background: Despite the adoption of pediatric-like chemotherapy protocols, the introduction of new immunotherapies and a better understanding of the oncogenic landscape, the outcome for adult patients with acute lymphoblastic leukemia (ALL) remain substantially dismal. The aim of the present study was to evaluate the outcome in terms of survival in a cohort of adult patients with ALL who received allogeneic hematopoietic stem cell transplantation (alloSCT) between 2013 and 2023.

Methods: This was a single-center observational retrospective study including all consecutive adult patients with ALL who received an alloSCT between April 2013 and April 2023 at the Stem Cell Transplant Center AOU Città della Salute e della Scienza of Torino. The primary endpoints were overall survival (OS), graft-versus-host disease (GVHD) Relapse-Free Survival (GRFS), Leukemia-Free Survival (LFS) and cumulative incidence (CI) of Non-Relapse Mortality (NRM).

Results: The 4-year OS and LFS were 63.4% and 48.1%, respectively, and the 1-year GRFS was 42.9%. The 1-year CI of bloodstream infections (BSI), invasive fungal infections and NRM were 38%, 7% and 18.4%, respectively. Multivariate analysis showed that the use of total body irradiation (TBI), a time interval from diagnosis to alloSCT 7 months and female gender were factors significantly associated with better OS. Relapse of the underlying malignancy and BSI were the main causes of death.

Conclusion: Our study suggests that alloSCT from a matched sibling donor (MSD) and alternative donors may be considered an effective tool for patients with ALL achieving a CR.

Keywords: acute lymphoblastic leukemia; allogeneic stem cell transplantation; total body irradiation.

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Conflict of interest statement

The authors have stated that they have no conflicts of interest.

Figures

Figure 1
Figure 1
GRFS (A), OS (B), LFS (C) and cumulative incidence of Non-Relapse Mortality (D) of 69 patients with ALL who received alloSCT.
See this image and copyright information in PMC

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