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Review
. 2024 Oct 23;10(6):53.
doi: 10.3390/ncrna10060053.

Cardiomyopathies: The Role of Non-Coding RNAs

Nicole Carabetta  1 , Chiara Siracusa  1 , Isabella Leo  2 , Giuseppe Panuccio  2   3 , Antonio Strangio  2 , Jolanda Sabatino  2 , Daniele Torella  2 , Salvatore De Rosa  1
Affiliations
Review

Cardiomyopathies: The Role of Non-Coding RNAs

Nicole Carabetta et al. Noncoding RNA. .

Abstract

Cardiomyopathies are the structural and functional disorders of the myocardium. Etiopathogenesis is complex and involves an interplay of genetic, environmental, and lifestyle factors eventually leading to myocardial abnormalities. It is known that non-coding (Nc) RNAs, including micro (mi)-RNAs and long non-coding (lnc) RNAs, play a crucial role in regulating gene expression. Several studies have explored the role of miRNAs in the development of various pathologies, including heart diseases. In this review, we analyzed various patterns of ncRNAs expressed in the most common cardiomyopathies: dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy. Understanding the role of different ncRNAs implicated in cardiomyopathic processes may contribute to the identification of potential therapeutic targets and novel risk stratification models based on gene expression. The analysis of ncRNAs may also be helpful to unveil the molecular mechanisms subtended to these diseases.

Keywords: cardiomyopathies; long non-coding RNAs; micro-RNAs; non-coding RNAs.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Non-Coding RNAs and their sources in the analyzed studies on cardiomyopathies. Figure created with Biorender; echocardiographic images are part of our archive.
Figure 2
Figure 2
Mechanisms of action of some well-known miRNAs in cardiomyopathies. Figure created with Biorender.
See this image and copyright information in PMC

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