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Review
. 2024 Oct 10:15:1418657.
doi: 10.3389/fendo.2024.1418657. eCollection 2024.

Management of medullary thyroid cancer based on variation of carcinoembryonic antigen and calcitonin

Bo Wang  1 , Jie Huang  2 , Li Chen  3
Affiliations
Review

Management of medullary thyroid cancer based on variation of carcinoembryonic antigen and calcitonin

Bo Wang et al. Front Endocrinol (Lausanne). .

Abstract

Carcinoembryonic antigen (CEA) and calcitonin (Ctn) are pivotal biomarkers in the diagnosis and management of medullary thyroid carcinoma (MTC). However, their diagnostic reliability in perioperative period remains a topic of ongoing debate. This review synthesizes researches on perioperative fluctuations in CEA and Ctn levels, and evaluates the impact of their different combinations on MTC diagnosis, treatment decisions, and prognosis. Our findings highlight it is crucial to understand and interpret the various combinations of CEA and Ctn fluctuations within a clinical context. Furthermore, to reduce diagnostic errors and improve patient outcomes, we recommend follow-up diagnostic and treatment protocols designed to address the potential pitfalls associated with the use of these biomarkers.

Keywords: calcitonin (Ctn); carcinoembryonic antigen (CEA); follow-up; medullary thyroid carcinoma (MTC); perioperative management.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Postoperative follow-up strategies based on changes in CEA and Ctn levels.
See this image and copyright information in PMC

References

    1. Randle RW, Balentine CJ, Leverson GE, Havlena JA, Sippel RS, Schneider DF, et al. . Trends in the presentation, treatment, and survival of patients with medullary thyroid cancer over the past 30 years. Surgery. (2017) 161:137–46. doi: 10.1016/j.surg.2016.04.053 - DOI - PMC - PubMed
    1. Ceolin L, Duval M, Benini AF, Ferreira CV, Maia AL. Medullary thyroid carcinoma beyond surgery: advances, challenges, and perspectives. Endocr Relat Cancer 26. (2019) 26:R499–R518. doi: 10.1530/ERC-18-0574 - DOI - PubMed
    1. Wells SA, Jr., Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, et al. . Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. (2015) 25:567–610. doi: 10.1089/thy.2014.0335 - DOI - PMC - PubMed
    1. Nicholson BD, Shinkins B, Pathiraja I, Roberts NW, James TJ, Mallett S, et al. . Blood CEA levels for detecting recurrent colorectal cancer. Cochrane Database Syst Rev 2015. (2015) 2015:Cd011134. doi: 10.1002/14651858.CD011134.pub2 - DOI - PMC - PubMed
    1. Nasralla A, Lee J, Dang J, Turner S. Elevated preoperative CEA is associated with subclinical nodal involvement and worse survival in stage I non-small cell lung cancer: a systematic review and meta-analysis. J Cardiothorac Surg. (2020) 15:318. doi: 10.1186/s13019-020-01353-2 - DOI - PMC - PubMed

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