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. 2024 Sep 23;16(9):e69975.
doi: 10.7759/cureus.69975. eCollection 2024 Sep.

The Oncologic Value of Transoral Resection in Early-Stage Laryngeal Squamous Cell Carcinoma of the Glottis: A Retrospective Study

Athanasios Ioannidis  1 , Georgios Louverdis  1 , Aristeidis I Giotakis  1   2 , Konstantinos Tarazis  1 , Efthymios Kyrodimos  1
Affiliations

The Oncologic Value of Transoral Resection in Early-Stage Laryngeal Squamous Cell Carcinoma of the Glottis: A Retrospective Study

Athanasios Ioannidis et al. Cureus. .

Abstract

Background and objective The treatment of early-stage laryngeal glottic cancer involves surgery or radiotherapy, and both have similar survival rates. However, discrepancies between systematic reviews in the literature point towards the continuous need for more data. In this study, we aimed to investigate the oncologic value of surgery at an ENT university department of a tertiary hospital in Greece. Materials and methods Patients with T1 or T2 laryngeal squamous cell carcinoma of the glottis who underwent transoral tumor resection between April 2014 and September 2021 at the hospital were deemed eligible for this study. Disease-free survival (DFS), local control rate (LCR), overall survival (OS), and laryngeal preservation were assessed. Results We enrolled 43 subjects with a median age of 67 years (range: 46-84 years). An overwhelming majority of the subjects were men (39/43). The most common stage was T1a (22/43 subjects). OS was 74 months and DFS was 67 months. We noted local recurrence in 7/43 subjects. Three subjects passed away after five years of follow-up. Eventually, total laryngectomy was performed in 4/43 subjects, two of whom initially suffered from a T2 glottic carcinoma. Conclusions Our results align with the findings of the systematic reviews supporting high survival rates, laryngeal preservation, and avoidance of radiotherapy complications observed after transoral surgery for early-stage laryngeal glottic carcinoma.

Keywords: laryngeal neoplasms; laryngeal tumors; laser; prognosis; surgical managment.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. IRB of General Hospital of Athens Hippokration issued approval N/A. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Kaplan-Meier survival curves for DFS in patients with T1 and T2 laryngeal glottic squamous cell carcinoma
Y-axis: survival probability. X-axis: DFS in months. Patients with T1 laryngeal glottic squamous cell carcinoma had significantly higher DFS time compared to patients with T2 laryngeal glottic squamous cell carcinoma (p=0.043) DFS: disease-free survival
Figure 2
Figure 2. Kaplan-Meier survival curves for OS in patients with T1 and T2 laryngeal glottic squamous cell carcinoma
Y-axis: survival probability. X-axis: OS in months. Patients with T1 laryngeal glottic squamous cell carcinoma had significantly higher OS time compared to patients with T2 laryngeal glottic squamous cell carcinoma (p=0.024) OS: overall survival
See this image and copyright information in PMC

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