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Review
. 2024 Sep 24;16(9):e70075.
doi: 10.7759/cureus.70075. eCollection 2024 Sep.

Efficacy of pCONUS Devices in the Management of Intracranial Aneurysms: Outcomes of 190 Patients

Hosam M Al-Jehani  1   2   3   4 , Ahmed Hafez Mousa  4   5 , May A AlHamid  6
Affiliations
Review

Efficacy of pCONUS Devices in the Management of Intracranial Aneurysms: Outcomes of 190 Patients

Hosam M Al-Jehani et al. Cureus. .

Abstract

Intracranial aneurysms (IAs) pose a significant health concern, necessitating effective treatment modalities. The pCONUS device has emerged as a promising option for managing complex IAs, particularly wide-necked bifurcation aneurysms. Evaluating its efficacy across multiple studies is essential for establishing therapeutic guidelines. A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify studies assessing the efficacy of pCONUS devices in treating cerebral aneurysms. PubMed, Google Scholar, and Scopus were searched for relevant articles published from January 1, 2000, to December 31, 2021. Inclusion criteria encompassed clinical trials examining pCONUS device benefits for ruptured or unruptured cerebral aneurysms. Data extraction and quality assessment were performed independently by two reviewers. Out of 390 initially identified articles, eight studies met the inclusion criteria. These studies collectively involved 190 participants with intracranial aneurysms. The sample sizes ranged from seven to 40 patients, predominantly in retrospective designs. Complete occlusion rates varied from 46.8% to 100%, with a mean diameter of treated aneurysms ranging from 2.5 mm to 8.83 mm. This systematic review suggests that pCONUS devices are feasible and effective for treating complex bifurcation cerebral aneurysms, with acceptable complication rates. Despite limitations such as retrospective study designs and limited follow-up durations, the findings support the beneficial role of pCONUS devices in managing challenging intracranial aneurysms. Larger collaborative efforts with longer follow-up durations are warranted to validate these findings and establish wider therapeutic guidelines.

Keywords: intracranial aneurysms (ias); pconus device; systematic review; therapeutic guidelines; wide-necked bifurcation aneurysms.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. PRISMA flowchart showing the study inclusion and exclusion process
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Figure 2
Figure 2. Forest plot for the utilization of pCONUS in the management of cerebral aneurysm
RE: random effect
Figure 3
Figure 3. Funnel plot for publication bias and heterogeneity
See this image and copyright information in PMC

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