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Review
. 2024 Oct;40(10):737-747.
doi: 10.1051/medsci/2024116. Epub 2024 Oct 25.

[The dengue vaccine: a major scientific challenge and a public health issue]

[Article in French]
Philippe Desprès  1 , Dominique Salmon  2 , Laurent Bellec  3 , André Cabié  4 , Marie-Lise Gougeon  5
Affiliations
Free article
Review

[The dengue vaccine: a major scientific challenge and a public health issue]

[Article in French]
Philippe Desprès et al. Med Sci (Paris). 2024 Oct.
Free article

Erratum in

Abstract
in English, French

Almost half of the world's population is exposed to the risk of transmission of the four dengue virus serotypes (DENV 1-4), by mosquitoes of the genus Aedes. A dengue vaccine is effective if it induces prolonged protective immunity against all circulating viral strains, irrespective of the age and infection history of the vaccinated subject. An effective vaccine strategy against dengue is based on the injection of live attenuated viruses in a tetravalent formulation. In this review, we present the most promising candidate vaccines against dengue, their successes and also the questions raised by the correlates of protection that have been adopted to assess their level of effectiveness against the disease.

Title: Le vaccin contre la dengue - Un défi scientifique majeur et un enjeu de santé publique.

Abstract: Près de la moitié de la population mondiale est exposée au risque de transmission des quatre sérotypes du virus de la dengue par les moustiques hématophages du genre Aedes. Pour être efficace, un vaccin contre la dengue doit induire une immunité protectrice prolongée contre l’ensemble des souches virales circulantes, et cela, indépendamment de l’âge et de l’historique d’infection du sujet vacciné. Une stratégie vaccinale performante contre la dengue repose sur l’injection de virus vivants atténués selon une formulation tétravalente. Dans cette revue, nous présentons les principaux candidats vaccins contre la dengue les plus aboutis, leur réussite mais aussi les interrogations suscitées au regard des corrélats de protection qui ont été adoptés nécessaires à l’évaluation de leur efficacité protectrice contre la maladie.

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References

    1. Guzman MG, Gubler DJ, Izquierdo A, et al. Dengue infection. Nat Rev Dis Primers. 2016 ; 2 : 16055.
    1. Balmaseda A, Hammond SN, Perez L, et al. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg 2006 ; 74 : 449–56.
    1. WHO. Dengue - global situation. https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON498.
    1. Messina JP, Brady OJ, Scott TW, et al. Global spread of dengue virus types : mapping the 70 year history. Trends Microbiol 2014 ; 22 : 138–46.
    1. Marques-Toledo CA, Bendati MM, Codeco CT, et al. Probability of dengue transmission and propagation in a non-endemic temperate area : conceptual model and decision risk levels for early alert, prevention and control. Parasit Vectors 2019 ; 12 : 38.

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