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Review
. 2024 Oct 14;12(20):2037.
doi: 10.3390/healthcare12202037.

High-Sensitivity Cardiac Troponin [hs-cTn] as a Valuable Biomarker for Pulmonary Hypertension Risk Stratification: A Contemporary Review of the Literature

Vijay Durga Pradeep Ganipineni  1 , Sahas Reddy Jitta  2 , Mohan Chandra Vinay Bharadwaj Gudiwada  3 , Jaswanth Rao Jasti  4 , Chaitra Janga  5 , Bhavyasri Merugu  6 , Revanth Reddy Bandaru  7 , Srikanth Puli  8 , Vikramaditya Samala Venkata  8 , Advait Vasavada  9 , Rupak Desai  10
Affiliations
Review

High-Sensitivity Cardiac Troponin [hs-cTn] as a Valuable Biomarker for Pulmonary Hypertension Risk Stratification: A Contemporary Review of the Literature

Vijay Durga Pradeep Ganipineni et al. Healthcare (Basel). .

Abstract

Background: Pulmonary hypertension (PH) can lead to cardiac failure, thereby significantly affecting life expectancy and quality of life. Due to inadequate disease surveillance and risk assessment, clinical challenges persist despite advances in diagnosis and treatment. We aimed to review the potential of high-sensitivity cardiac troponin (hs-cTn) as a biomarker for predicting outcomes in PH patients. Methods: A thorough examination of the PubMed and Google Scholar databases was conducted through March 2023. Studies involving adult PH patients and hsTn as a prognostic indicator of outcomes such as mortality, hospitalization, and disease progression were included, after screening their titles and abstracts. Two independent evaluators extracted data, with the quality assessed using the JBI critical appraisal tool. Results: This review uncovered eight studies that examined the prognostic value of hs-cTn in PH patients. Higher hs-cTn levels were associated with increased mortality and hospitalization rates, according to the studies. The severity of PH, cardiac dysfunction, right ventricular function, and systolic dysfunction were associated with hs-cTn. Multiple studies have demonstrated that hsTn has the potential to identify high-risk PH patients who could benefit from targeted therapies and increased clinical monitoring. Conclusions: This review suggests that hsTn may be a biomarker for PH risk stratification and prognosis. Across PH subtypes, elevated hsTn levels predict poor outcomes. However, large-scale prospective studies are needed to confirm hs-cTn's function in diagnosing pulmonary hypertension and determine its potential value in treatment.

Keywords: heart failure; high-sensitivity cardiac troponin; high-sensitivity troponin; mortality/outcomes; pulmonary hypertension/pulmonary artery hypertension.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Mechanisms of hs-Troponin elevation in pulmonary hypertension.
Figure 2
Figure 2
PRISMA chart.
See this image and copyright information in PMC

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