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Review
. 2024 Oct 5;13(10):938.
doi: 10.3390/antibiotics13100938.

Deciphering the Intricate Interplay in the Framework of Antibiotic-Drug Interactions: A Narrative Review

Andrei-Flavius Radu  1   2 , Simona Gabriela Bungau  1   3 , Raluca Anca Corb Aron  2 , Alexandra Georgiana Tarce  4 , Ruxandra Bodog  1 , Teodora Maria Bodog  1 , Ada Radu  1   3
Affiliations
Review

Deciphering the Intricate Interplay in the Framework of Antibiotic-Drug Interactions: A Narrative Review

Andrei-Flavius Radu et al. Antibiotics (Basel). .

Abstract

Drug interactions are a significant and integral part of the concept of medication-related adverse events, whether referring to potential interactions or those currently observed in real-world conditions. The high global consumption of antibiotics and their pharmacokinetic and pharmacodynamic mechanisms make antibiotic-drug interactions a key element that requires continuous study due to their clinical relevance. In the present work, the current state of knowledge on antibiotic-drug interactions, which are less studied than other drug-drug interactions despite their frequent use in acute settings, has been consolidated and updated. The focus was on the interactions of the commonly used antibiotics in clinical practice, on the characteristics of the geriatric population susceptible to interactions, and on the impact of online drug interaction checkers. Additionally, strategies for optimizing the management of these interactions, including spacing out administrations, monitoring, or avoiding certain combinations, are suggested. Sustained research and careful monitoring are critical for improving antibiotic safety and efficacy, especially in susceptible populations, to enhance precision in managing antibiotic-drug interactions.

Keywords: antibiotic-antibiotic interactions; antibiotic-drug interactions; antibiotics; drug interaction checker; drug-drug interactions; geriatric population; pharmacodynamics; pharmacokinetics.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Methodological strategies for selecting literature on antibiotics-drug interactions. MeSH, medical subject heading.
Figure 2
Figure 2
Variations in publication volume across search terms, highlighting the limited focus on antibiotic interactions.
Figure 3
Figure 3
Distribution of antibiotic interactions by severity from Drugs.com.
Figure 4
Figure 4
Chord diagrams showing the type of interaction based on the color of the bond between two drugs.
See this image and copyright information in PMC

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References

    1. Halawa E.M., Fadel M., Al-Rabia M.W., Behairy A., Nouh N.A., Abdo M., Olga R., Fericean L., Atwa A.M., El-Nablaway M., et al. Antibiotic Action and Resistance: Updated Review of Mechanisms, Spread, Influencing Factors, and Alternative Approaches for Combating Resistance. Front. Pharmacol. 2023;14:1305294. doi: 10.3389/fphar.2023.1305294. - DOI - PMC - PubMed
    1. Bacanlı M.G. The Two Faces of Antibiotics: An Overview of the Effects of Antibiotic Residues in Foodstuffs. Arch. Toxicol. 2024;98:1717–1725. doi: 10.1007/s00204-024-03760-z. - DOI - PMC - PubMed
    1. Aminov R.I. A Brief History of the Antibiotic Era: Lessons Learned and Challenges for the Future. Front. Microbiol. 2010;1:134. doi: 10.3389/fmicb.2010.00134. - DOI - PMC - PubMed
    1. Browne A.J., Chipeta M.G., Haines-Woodhouse G., Kumaran E.P.A., Hamadani B.H.K., Zaraa S., Henry N.J., Deshpande A., Reiner R.C.J., Day N.P.J., et al. Global Antibiotic Consumption and Usage in Humans, 2000–2018: A Spatial Modelling Study. Lancet Planet. Health. 2021;5:e893–e904. doi: 10.1016/S2542-5196(21)00280-1. - DOI - PMC - PubMed
    1. Chin K.W., Michelle Tiong H.L., Luang-In V., Ma N.L. An Overview of Antibiotic and Antibiotic Resistance. Environ. Adv. 2023;11:100331. doi: 10.1016/j.envadv.2022.100331. - DOI

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