Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 28;14(10):1037.
doi: 10.3390/jpm14101037.

Dynamic Soluble IL-6R/Soluble gp130 Ratio as a Potential Indicator for the Prostate Malignancy Phenotype-A Multicenter Case-Control Study

Cosmin-Victor Ene  1   2 , Bogdan Geavlete  1   2 , Cristian Mares  1   2 , Ilinca Nicolae  3 , Corina Daniela Ene  4   5
Affiliations

Dynamic Soluble IL-6R/Soluble gp130 Ratio as a Potential Indicator for the Prostate Malignancy Phenotype-A Multicenter Case-Control Study

Cosmin-Victor Ene et al. J Pers Med. .

Abstract

Objective: Prostate tumors, if prostate cancer or adenoma, represent a major public health challenge. Progress in research on inflammation has revealed a connection between inflammation, immunity, and cancer. In this context, this study aimed to find IL-6 signaling systemic abnormalities in the inflammatory tumor microenvironment.

Material and methods: This study was case-controlled, multicentered, and included 86 patients, 43 diagnosed with BPH and 43 diagnosed with PCa, between January 2019 and January 2020. The study group was homogenous and the studied parameters were IL-6 complex (IL-6, soluble receptor IL-6R, soluble glycoprotein gp130), acute phase proteins (C reactive protein-CRP, acid alpha1 glycoprotein-AGPA, ferritin, albumin, transferrin), and oxidative stress-associated variables (malondialdehyde-MDA, carbonylated protein-PCO, 8-hydroxy-deoxy guanosine-8-OHdG, total antioxidant status-bTAS).

Results: The inflammatory microenvironment determined IL-6 signaling alterations (over-regulation of sIL-6R and suppression of sgp130 in PCa versus BPH), changes in acute phase reaction markers (increased serum levels of CRP, AGPA, ferritin, and decreased serum levels of albumin, transferrin) that were much more evident in PCa compared to BPH, an imbalance between macromolecular oxidative damage (MDA, PCO, 8-OHdG) and endogenous antioxidants (TAS) that was more accentuated in PCa compared with BPH, and a representative association between the sIL-6R/sgp130 ratio and inflammatory/oxidative stress-related factors only in PCa patients.

Conclusions: Our study reconfirms the anterior concept that IL-6 promotes prostatic tumorigenesis. In this study, we first demonstrated that a high sIL-6R/sgp130 ratio facilitates prostate malignancy.

Keywords: IL-6 signaling; acute phase reaction; inflammation; microenvironment; oxidative stress; prostate tumors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic illustration of IL-6 signaling IL-interleukin; IL-6R-IL6 receptor; mIL-6R-membranar-IL-6R; gp130-glycoprotein; sIL-6R-soluble IL-6R; sgp130-soluble; gp130; jak/STAT-Janus kinase/signal transducers and activators of transcription; MAPK-Mitogen-activated protein kinase; and PI3K- Phosphoinositide 3-kinase.
See this image and copyright information in PMC

References

    1. Awedew A.F., Han H., Abbasi B., Abbasi-Kangevari M., Ahmed M.B., Almidani O., Amini E., Arabloo J., Argaw A.M., Athari S.S., et al. The global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Healthy Longev. 2022;3:e754–e776. doi: 10.1016/S2666-7568(22)00213-6. - DOI - PMC - PubMed
    1. National Cancer Institute . SEER Stat Fact Sheets: Prostate. National Cancer Institute; Bethesda, MD, USA: 2018.
    1. Nisticò P., Ciliberto G. Biological mechanisms linked to inflammation in cancer: Discovery of tumor microenvironment-related biomarkers and their clinical application in solid tumors. Int. J. Biol. Markers. 2020;35((Suppl. S1)):8–11. doi: 10.1177/1724600820906155. - DOI - PubMed
    1. Reinfeld B.I., Madden M.Z., Wolf M.M., Chytil A., Bader J.E., Patterson A.R., Sugiura A., Cohen A.S., Ali A., Do B.T., et al. Cell-programmed nutrient partitioning in the tumor microenvironment. Nature. 2021;593:282–288. doi: 10.1038/s41586-021-03442-1. - DOI - PMC - PubMed
    1. Ene C.D., Anghel A.E., Neagu M., Nicolae I. 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression. Mediators Inflamm. 2015;2015:904876. doi: 10.1155/2015/904876. - DOI - PMC - PubMed

LinkOut - more resources