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Comment
. 2024 Nov 1;327(5):H1303-H1305.
doi: 10.1152/ajpheart.00701.2024. Epub 2024 Oct 25.

Hypoxic neutrophils enflame the infarcted heart

Preston Stafford  1   2 , Ronald J Vagnozzi  1   2   3
Affiliations
Comment

Hypoxic neutrophils enflame the infarcted heart

Preston Stafford et al. Am J Physiol Heart Circ Physiol. .
No abstract available

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

Figure 1.
Figure 1.
Neutrophil survival via HIF2ɑ worsens post-MI outcomes. Summary of key findings from Piccolo et al. (3). HIF2ɑ activation in hypoxic neutrophils attenuates cell death and neutrophil clearance, which contributes to scarring and pathological remodeling after MI. HIF, hypoxia-inducible factor; cIAP1, cellular inhibitor of apoptosis protein 1; HRE, hypoxia-response element; MI, myocardial infarction. Images were created with a licensed version of BioRender.com.
See this image and copyright information in PMC

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References

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