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Comment
. 2024 Dec 1;327(6):H1387-H1389.
doi: 10.1152/ajpheart.00730.2024. Epub 2024 Oct 25.

Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects

Kylee S West  1 , Nathaniel D M Jenkins  1   2   3   4
Affiliations
Comment

Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects

Kylee S West et al. Am J Physiol Heart Circ Physiol. .
No abstract available

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

Figure 1.
Figure 1.
Association of chronological age with carotid-femoral pulse wave velocity (cf-PWV), flow-mediated dilation (FMD), follicle-stimulating hormone (FSH), and progesterone (P4) in women across the lifespan based on the findings of Wenner et al. (4), with a simple illustration of possible mechanisms linking reproductive aging-related increases in FSH and decreases in P4 with reduced endothelial function. The dissociation between chronological age and phenotypic changes consistent with vasculature aging, but close relation and substantial mediation (67%) of the age and vascular function association by reproductive hormone concentrations highlight the importance of reproductive aging in age-related cardiovascular risk among women. At the same time, 33% of the association between age and changes in vascular function remained unaccounted for after considering sex hormones and were not explained by traditional cardiometabolic risk factors such as cholesterol and blood pressure. Thus, identification of the unidentified mediating factors represents a unique opportunity to identify intervenable targets to improve cardiovascular risk in women. CVD, cardiovascular disease; MCP-1, monocyte chemoattractant protein-1; NO, nitric oxide; p-eNOS, phosphorylated endothelial nitric oxide synthase; VCAM-1, vascular cell adhesion molecule-1. Created using BioRender.com.
See this image and copyright information in PMC

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