Biosensors for autoimmune diseases

Abstract

Diagnosis of autoimmune diseases (ADs) is usually based on symptoms and laboratory tests that measure the occurrence of serological and genetic biomarkers such as peptides, autoantibodies, and complement proteins. Early detection of AD is essential to reduce the severity of symptoms and organ damage as a result of progressive disease. Biosensors are tools that convert biochemical signals produced by molecular elements into optical, electrical, and other physical signals for analysis. In recent years, peptides, antigens, aptamers, autoantibodies, and other biomolecules have provided suitable diagnostic features for development of biosensors in detecting and follow up the diagnoses and treatment of diseases. This study reviews the introducing of different biomarkers in ADs with the novel vision to use of biosensor technology for research and development in this regard. Therefore, this study has the required innovation for using biosensor technology with more attention to electrochemical based biosensors to developing, targeting and designing the easy applicable and available diagnostic and response to treatment products using key biomolecules for ADs. It will help readers to understand the research trends of biosensors in ADs and further advance the development of this paramount field.

Keywords: Antibody; Aptamer; Autoimmunity; Biomarker; Biosensor; MicroRNA.