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Review
. 2024 Dec;73(12):2231-2247.
doi: 10.1007/s00011-024-01960-y. Epub 2024 Oct 26.

IL-1 receptor antagonist: etiological and drug delivery systems overview

Anand Ubhe  1
Affiliations
Review

IL-1 receptor antagonist: etiological and drug delivery systems overview

Anand Ubhe. Inflamm Res. 2024 Dec.

Abstract

Objective: This article is aims to provide an overview of studies reported in the literature to investigate the etiological role of IL-1/IL-1ra in various disease conditions and the different drug delivery systems developed to achieve IL-1ra as a possible therapeutic option.

Methods: Studies reported in PubMed, Google scholar, and other open-source literature related to etiological involvement of IL-1ra in pathophysiological conditions and various drug delivery schemes developed for IL-1ra for its efficacy evaluation as a possible treatment for different disease conditions were surveyed.

Results and conclusions: The pathophysiological conditions involving IL-1/IL-1 ra spanned CNS-related disorders, Diabetes, Cardiac disorders, Ocular disease conditions, Gastrointestinal conditions, Tumor growth & metastasis, and miscellaneous conditions. The drug delivery systems developed for IL-1ra included a commercial drug product, Gene therapy, Antibody fusions, Extended-release delivery systems, and Pegylated-IL-1ra systems.

Keywords: Drug delivery; Etiology; Interleukin-1; Interleukin-1 receptor antagonist.

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Conflict of interest statement

Declarations. Competing interests: Anand Ubhe is an employee of AbbVie and may own AbbVie stock. AbbVie contributed to reviewing, and approval of the final publication.

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References

    1. Arend WP, Palmer G, Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 2008;223:20–38. - PubMed - DOI
    1. Malemud CJ. Anticytokine therapy for osteoarthritis: evidence to date. Drugs Aging. 2010;27:95–115. - PubMed - DOI
    1. Kraus VB, Birmingham J, Stabler TV, Feng S, Taylor DC, Moorman CT 3rd, et al. Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012;20:271–8. - DOI
    1. Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, et al. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a Randomized Clinical Trial. JAMA Ophthalmol. 2013;131:715–23. - PubMed - PMC - DOI
    1. Papathanasiou E, Conti P, Carinci F, Lauritano D, Theoharides TC. IL-1 Superfamily members and periodontal diseases. J Dent Res. 2020;99:1425–34. - PubMed - PMC - DOI

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