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Review
. 2024 Oct 19;25(20):11258.
doi: 10.3390/ijms252011258.

Cannabis-Based Phytocannabinoids: Overview, Mechanism of Action, Therapeutic Application, Production, and Affecting Environmental Factors

Marta Jurga  1 , Anna Jurga  2 , Kacper Jurga  1 , Bartosz Kaźmierczak  2 , Katarzyna Kuśmierczyk  3 , Mariusz Chabowski  1   4
Affiliations
Review

Cannabis-Based Phytocannabinoids: Overview, Mechanism of Action, Therapeutic Application, Production, and Affecting Environmental Factors

Marta Jurga et al. Int J Mol Sci. .

Abstract

This review provides an overview of cannabis-based phytocannabinoids, focusing on their mechanisms of action, therapeutic applications, and production processes, along with the environmental factors that affect their quality and efficacy. Phytocannabinoids such as THC (∆9-tetrahydrocannabinol), CBD (cannabidiol), CBG (cannabigerol), CBN (cannabinol), and CBC (cannabichromene) exhibit significant therapeutic potential in treating various physical and mental health conditions, including chronic pain, epilepsy, neurodegenerative diseases, skin disorders, and anxiety. The cultivation of cannabis plays a crucial role in determining cannabinoid profiles, with indoor cultivation offering more control and consistency than outdoor methods. Environmental factors such as light, water, temperature, humidity, nutrient management, CO2, and the drying method used are key to optimizing cannabinoid content in inflorescences. This review outlines the need for broader data transfer between the health industry and technological production, especially in terms of what concentration and cannabinoid ratios are effective in treatment. Such data transfer would provide cultivators with information on what environmental parameters should be manipulated to obtain the required final product.

Keywords: CBD; indoor cultivation; medical cannabis; phytocannabinoids; therapeutic use.

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

    1. de Brito Siqueira A.L.G., Cremasco P.V.V., Bahú J.O., Pioli da Silva A., Melo de Andrade L.R., González P.G.A., Crivellin S., Cárdenas Concha V.O., Krambeck K., Lodi L., et al. Phytocannabinoids: Pharmacological Effects, Biomedical Applications, and Worldwide Prospection. J. Tradit. Complement. Med. 2023;13:575–587. doi: 10.1016/j.jtcme.2023.08.006. - DOI - PMC - PubMed
    1. Gülck T., Møller B.L. Phytocannabinoids: Origins and Biosynthesis. Trends Plant Sci. 2020;25:985–1004. doi: 10.1016/j.tplants.2020.05.005. - DOI - PubMed
    1. Blebea N.M., Pricopie A.I., Vlad R.A., Hancu G. Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use. Int. J. Mol. Sci. 2024;25:4204. doi: 10.3390/ijms25084204. - DOI - PMC - PubMed
    1. Dawidowicz A.L., Olszowy-Tomczyk M., Typek R. CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as Antioxidant Agents and Their Intervention Abilities in Antioxidant Action. Fitoterapia. 2021;152:104915. doi: 10.1016/j.fitote.2021.104915. - DOI - PubMed
    1. Pourseyed Lazarjani M., Torres S., Hooker T., Fowlie C., Young O., Seyfoddin A. Methods for Quantification of Cannabinoids: A Narrative Review. J. Cannabis Res. 2020;2:35. doi: 10.1186/s42238-020-00040-2. - DOI - PMC - PubMed

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