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Review
. 2024 Oct 8;12(10):2030.
doi: 10.3390/microorganisms12102030.

Interplay between Lung Diseases and Viral Infections: A Comprehensive Review

Chahat Suri  1 , Babita Pande  2 , Lakkakula Suhasini Sahithi  3 , Tarun Sahu  2 , Henu Kumar Verma  4
Affiliations
Review

Interplay between Lung Diseases and Viral Infections: A Comprehensive Review

Chahat Suri et al. Microorganisms. .

Abstract

The intricate relationship between chronic lung diseases and viral infections is a significant concern in respiratory medicine. We explore how pre-existing lung conditions, including chronic obstructive pulmonary disease, asthma, and interstitial lung diseases, influence susceptibility, severity, and outcomes of viral infections. We also examine how viral infections exacerbate and accelerate the progression of lung disease by disrupting immune responses and triggering inflammatory pathways. By summarizing current evidence, this review highlights the bidirectional nature of these interactions, where underlying lung diseasesincrease vulnerability to viral infections, while these infections, in turn, worsen the clinical course. This review underscores the importance of preventive measures, such as vaccination, early detection, and targeted therapies, to mitigate adverse outcomes in patients with chronic lung conditions. The insights provided aim to inform clinical strategies that can improve patient management and reduce the burden of chronic lung diseases exacerbated by viral infections.

Keywords: exacerbation; interaction; lung disease; pathway; therapeutics; viral infection.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Overview of viral infections, pathway, and consequences in chronic lung disease.“Created in BioRender. Pande, B. (2024) BioRender.com/v50i654 (accessed on 25 August 2024)”.
Figure 2
Figure 2
Preventive measures, targeted treatment approaches, diagnostic and management challenges, and future directions for CLD patients during viral infection periods. “Created in BioRender. Pande, B. (2024) BioRender.com/o38j486 (accessed on 25 August 2024)”.
See this image and copyright information in PMC

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