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Review
. 2024 Sep 29;16(10):1275.
doi: 10.3390/pharmaceutics16101275.

Annatto (Bixa orellana)-Based Nanostructures for Biomedical Applications-A Systematic Review

Vitória Regina Pereira da Silva  1   2 , Natália Ornelas Martins  1 , Carolina Ramos Dos Santos  1   3 , Elysa Beatriz de Oliveira Damas  1   4 , Paula Lauane Araujo  1   3 , Gabriella de Oliveira Silva  1   4 , Graziella Anselmo Joanitti  1   2   4 , Marcella Lemos Brettas Carneiro  1   3   4
Affiliations
Review

Annatto (Bixa orellana)-Based Nanostructures for Biomedical Applications-A Systematic Review

Vitória Regina Pereira da Silva et al. Pharmaceutics. .

Abstract

Plants are a source of valuable organic chemical compounds with complex structures rich in therapeutic activities. The encapsulation of compounds in nanostructured systems is an alternative to avoid limitations, such as instability and low solubility, and to promote therapeutic use. The objective of the present review was to summarize the data in the literature on the physicochemical characteristics, biomedical efficacy, and toxicity of nanostructures containing extracts and oils obtained from annatto (Bixa orellana). For this, searches were conducted in the CINAHL, LILACS, Embase, FSTA, MEDLINE, ProQuest, PubMed, ScienceDirect, Scopus, and Web of Science databases. Studies that carried out the development, physical-chemical characterization, and evaluation of therapeutic efficacy and/or in vitro, in vivo, or clinical toxicity of nanostructures containing extracts and oils derived from annatto were included in the review. Of the 708 articles found, nine met the inclusion criteria. The included studies developed different nanostructures (nanofibers, nanocochleates, chitosan, lipid, polymeric, and metallic nanoparticles). These nanostructures showed leishmanicidal, photoprotective, antioxidant, antimicrobial, and immunomodulatory efficacy, and tissue regeneration potential with no or low toxic effects in the tested models. Thus, the present work supports the nanostructuring of annatto extracts and oils as a relevant approach to the development of new technologies for biomedical applications.

Keywords: Bixa orellana; annatto; biomedical application; extract; nanotechnology; oil; toxicity.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Number of publications listed in Scopus database by regions or countries. Data were obtained on 6 June 2023.
Figure 2
Figure 2
Bibliometric study of publications listed in the Scopus database, with MeSH terms for bixaceae and nanomaterials, using the VOSviewer program (version 1.6.18), with at least five co-occurrences and full count configurations. Data were obtained on 8 August 2023.
Figure 3
Figure 3
PRISMA flow diagram.
See this image and copyright information in PMC

References

    1. Majumdar M., Shivalkar S., Pal A., Verma M.L., Sahoo A.K., Roy D.N. Biotechnological Production of Bioactive Compounds. Elsevier; Amsterdam, The Netherlands: 2020. Nanotechnology for Enhanced Bioactivity of Bioactive Compounds; pp. 433–466.
    1. Enayati A., Rezaei A., Falsafi S.R., Rostamabadi H., Malekjani N., Akhavan-Mahdavi S., Kharazmi M.S., Jafari S.M. Bixin-Loaded Colloidal Nanodelivery Systems, Techniques and Applications. Food Chem. 2023;412:135479. doi: 10.1016/j.foodchem.2023.135479. - DOI - PubMed
    1. Andréo-Filho N., Bim A.V.K., Kaneko T.M., Kitice N.A., Haridass I.N., Abd E., Santos Lopes P., Thakur S.S., Parekh H.S., Roberts M.S., et al. Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and In Vitro and In Vivo Human Skin Permeation and Toxicity. Ski. Pharmacol. Physiol. 2018;31:1–9. doi: 10.1159/000481691. - DOI - PubMed
    1. Muddapur U.M., Turakani B., Jalal N.A., Ashgar S.S., Momenah A.M., Alshehri O.M., Mahnashi M.H., Shaikh I.A., Khan A.A., Dafalla S.E. Phytochemical Screening of Bixa orellana and Preliminary Antidiabetic, Antibacterial, Antifibrinolytic, Anthelmintic, Antioxidant, and Cytotoxic Activity against Lung Cancer (A549) Cell Lines. J. King Saud Univ.-Sci. 2023;35:102683. doi: 10.1016/j.jksus.2023.102683. - DOI
    1. Kusmita L., Franyoto Y.D., Mutmainah M., Puspitaningrum I., Nurcahyanti A.D.R. Bixa orellana L. Carotenoids: Antiproliferative Activity on Human Lung Cancer, Breast Cancer, and Cervical Cancer Cells In Vitro. Nat. Prod. Res. 2022;36:6421–6427. doi: 10.1080/14786419.2022.2036144. - DOI - PubMed

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