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. 2024 Oct 13;29(20):4845.
doi: 10.3390/molecules29204845.

Ferric Chloride Promoted Glycosidation of Alkyl Thioglycosides

Lacie M Ridgway  1 , Anupama Das  1 , Melanie L Shadrick  1 , Alexei V Demchenko  1
Affiliations

Ferric Chloride Promoted Glycosidation of Alkyl Thioglycosides

Lacie M Ridgway et al. Molecules. .

Abstract

Reported herein is a new reaction for glycosylation with thioglycosides in the presence of iron(III) chloride. Previously, FeCl3 was used for the activation of thioglycosides as a Lewis acid co-promoter paired with NIS. In the reported process, although 5.0 equiv of FeCl3 are needed to activate thioglycosides most efficiently, no additives were used, and the reactions with reactive glycosyl donors smoothly proceeded to completion in 1 h at 0 °C. This work showcases a new direction in developing glycosylation methods using greener and earth-abundant activators.

Keywords: carbohydrates; ferric chloride; glycosylation; green chemistry; thioglycosides.

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Conflict of interest statement

The authors declare no conflicts of interest.

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