Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration

Mingchen Xiong^{1

2

3

4}, Xinling Yang^{1

2

3

4}, Ziwei Shi^{5

6}, Jiangbing Xiang⁷, Huanhuan Gao^{1

2

3

4}, Shuaifei Ji^{1

2

3

4}, Yingying Li^{1

2

3

4}, Wei Pi⁴, Huating Chen⁴, Hongliang Zhang^{1

2

3

4}, Mengyang Wang^{1

2

3

4}, Yan Li^{1

2

3

4}, Yiyue Hong^{1

2

3

4}, Dongsheng Liu⁸, Xiaobing Fu^{1

2

3

4}, Yuanchen Dong^{5

6}, Xiaoyan Sun^{1

2

3

4}

Affiliations

¹ Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, Beijing, 100048, P. R. China.
² State Key Laboratory of Trauma and Chemical Poisoning, Beijing, 100048, P. R. China.
³ PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Beijing, 100048, P. R. China.
⁴ Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing, 100048, P. R. China.
⁵ CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
⁷ State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, P. R. China.
⁸ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

PMID: 39460410
DOI: 10.1002/adma.202407322

Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration

Mingchen Xiong et al. Adv Mater. 2024 Dec.

. 2024 Dec;36(50):e2407322.

doi: 10.1002/adma.202407322. Epub 2024 Oct 25.

Authors

Affiliations

¹ Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, Beijing, 100048, P. R. China.
² State Key Laboratory of Trauma and Chemical Poisoning, Beijing, 100048, P. R. China.
³ PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Beijing, 100048, P. R. China.
⁴ Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing, 100048, P. R. China.
⁵ CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
⁷ State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, P. R. China.
⁸ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

PMID: 39460410
DOI: 10.1002/adma.202407322

Abstract

Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration-directing artificial skin (RDAS) system is presented, which is based on the rational design of multi-layered hydrogels that closely mimic natural skin matrices. By leveraging the programmability and architectural rigidity of DNA components, without the need for exogenous cell transplantation, such RDAS effectively minimizes tissue fibrosis by accurately guiding the regenerative process in wound fibroblasts, enabling rapid scarless wound repair, restoration of dermal function, and successful in situ regeneration of multiple appendages, such as hair follicles (HFs), sebaceous glands (SGs), and sweat glands (SwGs). Therefore, the RDAS offers a cell-free antiscarring therapeutic strategy for regenerative wound healing, resulting in improved outcomes. This innovative approach holds great potential for future clinical applications and burn rehabilitation.

Keywords: DNA supramolecular hydrogel; microenvironment; scar; skin appendage regeneration; wound healing.

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References

1. P. D'Arpa, K. P. Leung, Adv. Wound Care 2022, 11, 428.
1. C. Zhang, D. Yang, T.‐B. Wang, X. Nie, G. Chen, L.‐H. Wang, Y.‐Z. You, Q. Wang, Biomater. Sci. 2023, 11, 288.
1. L. B. Baker, Temp 2019, 6, 211.
1. W. H. G. Lv, M. Wu, Y. P. G. Ren, X. Luo, W. J. Hu, Q. Zhang, Y. P. G. Wu, Mol. Med. Rep. 2021, 23, 1.
1. L. R. Jones, W. Young, G. Divine, I. Datta, K. M. Chen, D. Ozog, M. J. Worsham, Dis. Markers 2015, 2015, 943176.

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Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration

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Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration

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