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. 2024 Oct 26;316(10):709.
doi: 10.1007/s00403-024-03461-8.

A marker of systemic inflammation in hidradenitis suppurativa patients without cardiovascular disease: aortic arch calcification

Uğur Köktürk  1 , Naile Eriş Güdül  2 , İlke Erbay  2 , Pelin Ertop Doğan  3 , Emel Hazinedar  3 , Furkan Kısa  2 , Rafet Koca  3 , Ahmet Avcı  2
Affiliations

A marker of systemic inflammation in hidradenitis suppurativa patients without cardiovascular disease: aortic arch calcification

Uğur Köktürk et al. Arch Dermatol Res. .

Abstract

Background: In this study, we aimed to investigate whether there is a relationship between aortic arch calcification (AAC) and hidradenitis suppurativa (HS) in HS patients without cardiovascular disease.

Methods: In this study, patients over 18 years of age who applied to the dermatology outpatient clinic between January 2023 and February 2024 were followed up with the diagnosis of HS without cardiovascular disease, and a healthy control group matched in terms of age and gender were included retrospectively.

Results: In total, 130 patients with HS without cardiovascular disease and 130 control patients were included in the study. AAC was significantly higher in the HS group compared to the control group (p = 0.028). In the multivariate analysis, we found that age and HS were independent predictors of AAC (OR: 1.048 (1.009-1.089); p = 0.015, OR: 3.158 (1.181-8.445); p = 0.022, respectively). When we divided the groups as having AAC (grade 1-3) and not having AAC (grade 0), the rate of HS disease was significantly higher in the group with AAC compared to the group without AAC (75.0% vs. 47.5% p = 0.010).

Conclusions: AAC is observed more frequently in patients with HS without cardiovascular disease than in healthy individuals. Moreover, HS can be considered as an independent predictor of AAC. AAC may contribute to developing treatment strategies in HS patients without cardiovascular disease.

Keywords: Aortic arch calcification; Cardiovascular disease; Hidradenitis suppurativa; Systemic inflammation.

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References

    1. Gulliver W, Zouboulis CC, Prens E, Jemec GB, Tzellos T (2016) Evidence-based approach to the treatment of hidradenitis suppurative/acneinversa, based on the European guidelines for hidradenitis suppurativa. Rev Endocr Metab Disord 17(3):343–351 - DOI - PubMed - PMC
    1. Goldburg SR, Strober BE, Payette MJ (2020) Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis. J Am Acad Dermatol 82(5):1045–1058 - DOI - PubMed
    1. Dauden E, Lázaro P, Aguilar MD, Blasco AJ, Suarez C, Marín I et al (2018) Recommendations for the management of comorbidity in hidradenitis suppurativa. J Eur Acad Dermatol Venereol 32:129–144 - DOI - PubMed
    1. Kimball AB, Sundaram M, Gauthier G, Guérin A, Pivneva I, Singh R et al (2018) The comorbidity burden of hidradenitis suppurativa in the United States: a claim data analysis. Dermatol Ther (Heidelb) 8:557–569 - DOI - PubMed
    1. Kohorst JJ, Kimball AB, Davis MD (2015) Systemic associations of hidradenitis suppurativa. J Am Acad Dermatol 73:27–35 - DOI

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