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Comparative Study
. 1986 Mar;149(2):251-4.
doi: 10.1016/0042-6822(86)90127-3.

Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus

M P Kiley, J Wilusz, J B McCormick, J D Keene
Comparative Study

Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus

M P Kiley et al. Virology. 1986 Mar.

Abstract

The 3' RNA base sequences of several Marburg (MBG) and Ebola (EBO) virus isolates have been determined. A comparison of these 3' terminal noncoding sequences with those of other negative strand RNA viruses suggests a unique phylogenic niche for Marburg and Ebola viruses. The translation initiation site and 35 N-terminal amino acids of the 3' proximal coding gene of a Zaire strain of Ebola virus was predicted. In addition, putative leader RNA sequences preceding the first gene are discussed in terms of possible regulatory functions.

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