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. 2024 Oct;14(10):e70007.
doi: 10.1002/clt2.70007.

Pregnancy impacts allergy-related differences in the response to a type-1 stimulus, staphylococcal enterotoxin A

Claudia Arasa  1 , Niamh Hyland  1 , Caroline Nilsson  2   3 , Eva Sverremark-Ekström  1
Affiliations

Pregnancy impacts allergy-related differences in the response to a type-1 stimulus, staphylococcal enterotoxin A

Claudia Arasa et al. Clin Transl Allergy. 2024 Oct.
No abstract available

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Conflict of interest statement

ESE has received honoraria for lectures and a grant for another research project from BioGaia AB. CN report grants to institution from Aimmune Therapeutics a Nestlé Company and Lecture fees from: MEDA ALK; Thermofisher and GSK. The other authors have no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
T cell responses to SEA. (A) Graphical representation of the cohort and the donors used. (B) Superantigen presentation to T‐cells by APCs. PBMCs were cultured and stimulated with SEA for 48h: (C) Ratio of CD4+ T‐cells expressing Tbet normalized to the unstimulated. (D) Secreted levels of IFN‐γ and TNF. (E) Ratio of CD4+ T‐cells expressing GATA3 normalized to the unstimulated. (F) Secreted levels of IL‐5 and IL‐13. (G) Proportion of IFN‐γ‐producing conventional T cells. Longitudinal assessment of the IFN‐γ production upon SEA during (○) and out of pregnancy (◊) in non‐allergic (H) and allergic (I) women. (n = 5–28).
FIGURE 2
FIGURE 2
Unconventional lymphocyte and APC responses to SEA. (A) Schematic representation of the contribution of APCs, conventional T‐cells and unconventional lymphocytes in the response to SEA. (B) Proportion of IFN‐γ‐producing MAIT cells, γδ T cells and NK cells. (C) Longitudinal assessment of the IFN‐γ production upon SEA during and out of pregnancy in MAIT, γδ T and NK cells in allergic women. (D) Transcriptional activation of CD14, CD16, CD163, HLADR, CD80, CD274 and IL12 in PBMCs, normalized to a housekeeping gene. (n = 5–28).
See this image and copyright information in PMC

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