Management of human leukocyte antigen-mediated platelet transfusion refractoriness: Brief synopsis and recent literature review

Affiliations

¹ Division of Hematology/Transfusion, Fred Hutch Cancer Center/University of Washington, Seattle, Washington, USA.
² Vitalant Medical Affairs, Scottsdale, Arizona, USA.
³ National Institutes of Health, Clinical Center, Bethesda, Maryland, USA.
⁴ Center for Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
⁵ OneBlood, Orlando, Florida, USA.
⁶ Laboratory Medicine and Pathology, College of Medicine and Science, Mayo Clinic, Rochester, Minnesota, USA.
⁷ Histocompatibility and Immunogenetics Laboratory, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.
⁸ HLA Laboratory, Emory University School of Medicine, Atlanta, Georgia, USA.
⁹ Miller School of Medicine, Miami, Florida, USA.
¹⁰ Department of Laboratory Medicine, University of California, San Diego, California, USA.

Review

Sandhya R Panch et al. Transfusion. 2024 Dec.

. 2024 Dec;64(12):2380-2390.

doi: 10.1111/trf.18036. Epub 2024 Oct 27.

¹ Division of Hematology/Transfusion, Fred Hutch Cancer Center/University of Washington, Seattle, Washington, USA.
² Vitalant Medical Affairs, Scottsdale, Arizona, USA.
³ National Institutes of Health, Clinical Center, Bethesda, Maryland, USA.
⁴ Center for Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
⁵ OneBlood, Orlando, Florida, USA.
⁶ Laboratory Medicine and Pathology, College of Medicine and Science, Mayo Clinic, Rochester, Minnesota, USA.
⁷ Histocompatibility and Immunogenetics Laboratory, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.
⁸ HLA Laboratory, Emory University School of Medicine, Atlanta, Georgia, USA.
⁹ Miller School of Medicine, Miami, Florida, USA.
¹⁰ Department of Laboratory Medicine, University of California, San Diego, California, USA.

No abstract available

Keywords: blood component preparations; hematology – platelets; platelet transfusion.

References

1. Pavenski K, Rebulla P, Duquesnoy R, Saw CL, Slichter SJ, Tanael S, et al. Efficacy of HLA‐matched platelet transfusions for patients with hypoproliferative thrombocytopenia: a systematic review. Transfusion. 2013;53:2230–2242.
1. Sypek M, Kausman J, Holt S, Hughes P. HLA epitope matching in kidney transplantation: an overview for the general nephrologist. Am J Kidney Dis. 2018;71:720–731.
1. Kopko PM, Warner P, Kresie L, Pancoska C. Methods for the selection of platelet products for alloimmune‐refractory patients. Transfusion. 2015;55:235–244.
1. Duquesnoy RJ, Filip DJ, Rodey GE, Rimm AA, Aster RH. Successful transfusion of platelets "mismatched" for HLA antigens to alloimmunized thrombocytopenic patients. Am J Hematol. 1977;2:219–226.
1. Stanworth SJ, Navarrete C, Estcourt L, Marsh J. Platelet refractoriness – practical approaches and ongoing dilemmas in patient management. Br J Haematol. 2015;171:297–305.