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. 2024 Oct;7(10):e70040.
doi: 10.1002/cnr2.70040.

Assessing the Concordance of Clinical and Pathological Diagnoses in Basal Cell Carcinoma Among the Iranian Population: A Cross-Sectional Analysis of 229 Cases

Fatemeh Farshad  1 , Elham Behrangi  2 , Alireza Jafarzadeh  2 , Masoumeh Roohaninasab  2 , Nasrin Shayanfar  3 , Zeinab Aryanian  4   5 , Parvaneh Hatami  4 , Azadeh Goodarzi  2
Affiliations

Assessing the Concordance of Clinical and Pathological Diagnoses in Basal Cell Carcinoma Among the Iranian Population: A Cross-Sectional Analysis of 229 Cases

Fatemeh Farshad et al. Cancer Rep (Hoboken). 2024 Oct.

Abstract

Background: Nonmelanoma skin cancer (NMSC) is the most prevalent malignancy globally, with basal cell carcinoma (BCC) being the most common type.

Aims: This study aims to evaluate the concordance between clinical and pathological diagnoses of BCC, emphasizing the importance of early detection.

Methods and results: In this cross-sectional study, we conducted a retrospective review of clinical and pathological records for 229 patients diagnosed with BCC between 2020 and 2024. The analysis focused on gender, age, lesion location, and diagnostic accuracy. Among the 229 patients, 193 were men (84.3%), and 131 (57.2%) had recorded clinical diagnoses. The mean age of diagnosed patients was 67.72 years. Lesions were primarily located on the scalp (29.5%), face (26.4%), and nose (13.9%). Of the pathological evaluations, 184 cases (80.3%) confirmed BCC, while 45 cases had alternative diagnoses. Notably, 94.6% of clinically diagnosed patients were suspected to have BCC by their physicians. A significant portion of cases (42%) lacked prior clinical diagnoses, reflecting a potential gap in education among nondermatologists regarding BCC recognition.

Conclusion: The study found high concordance between clinical and pathological diagnoses of BCC, underscoring the need for improved clinical assessment skills among healthcare providers. Collaboration with dermatologists is essential for accurate diagnosis and improved patient outcomes. Enhanced training in recognizing BCC symptoms is recommended to address the identified gaps in clinical suspicion.

Keywords: clinical assessment; diagnostic accuracy; histopathological findings; referral patterns; skin cancer education.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Locations (a) and subtypes (b) of the pathologically confirmed lesions included in the study.
FIGURE 2
FIGURE 2
The frequency of suspected and nonsuspected BCC lesion in each location.
See this image and copyright information in PMC

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