Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease

Abstract

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP^NL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP^NL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.

Keywords: Kaplan-Meier estimate; amyloid-beta; survival curve.

Figure 1 –

Survival and longevity analysis of C57BL/6, APP/PS1, and APP^NL-F/NL-F mice Kaplan Meier curve is shown as a solid line, 95% confidence limits are expressed as dotted lines. Survival curves comparing between sex (Fig. 1A) and between genotypes (Fig. 1B). Minimal longevity between sex (Fig. 1C) and genotype (Fig. 1D) comparisons for the shortest surviving 20%. Maximal longevity between sex (Fig. 1E) and genotype (Fig. 1F) comparisons for the oldest surviving 20%.