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. 2024 Oct 11:15:1431223.
doi: 10.3389/fendo.2024.1431223. eCollection 2024.

The relationship between oxidative balance score and circadian syndrome: evidence from the NHANES 2005-2018

Lin Xie  1 , Juan Li  1 , Mingzhi Xu  1 , Yahan Lei  1 , Xushan Chen  2 , Jiajia Xie  2
Affiliations

The relationship between oxidative balance score and circadian syndrome: evidence from the NHANES 2005-2018

Lin Xie et al. Front Endocrinol (Lausanne). .

Abstract

Background: The oxidative balance score (OBS) is a composite indicator that evaluates the balance between pro-oxidants and antioxidants in one's diet and lifestyle. However, the relationship between OBS and circadian syndrome (CircS) has remained unexplored. This investigation aimed to determine a correlation between OBS and CircS.

Methods: This population-based study examined 7,202 participants from the 2005 to 2018 National Health and Nutrition Examination Survey (NHANES), 1,433 of whom had CircS. We utilized weighted multivariate logistic regression, trend tests, subgroup analysis, and interaction tests to evaluate the correlation between OBS (total OBS, dietary OBS, and lifestyle OBS) and CircS. Restricted cubic splines (RCS) models and threshold effect analysis were used to explore nonlinear relationships.

Results: Multivariate logistic regression analysis indicated that the protective factor for CircS was a high OBS level (total OBS: Odds ratio (OR) = 0.95, 95% Confidence interval (CI): 0.93-0.97; dietary OBS: OR = 0.98, 95% CI: 0.96-1.00; lifestyle OBS: OR = 0.65, 95% CI: 0.61-0.69). Compared to the quartile 1 group, OBS (total OBS, dietary OBS, and lifestyle OBS) was negatively and statistically significantly associated with the risk of developing Circs in the quartile 4 group (total OBS: OR = 0.47, 95% CI: 0.32-0.70; dietary OBS: OR = 0.69, 95% CI: 0.48-0.99; lifestyle OBS: OR = 0.07, 95% CI: 0.04-0.11). According to subgroup analysis and interaction tests, there was an interaction effect between the association of lifestyle OBS and CircS in terms of education level (p for interaction = 0.01). Furthermore, we observed a nonlinear negative relationship between lifestyle OBS and CircS prevalence, with inflection points at 6 (p for nonlinearity = 0.002).

Conclusion: The results showed a substantial negative connection between OBS and CircS. Encouraging foods filled with antioxidants and antioxidant-rich lifestyles may reduce the risk of CircS.

Keywords: NHANES; circadian rhythm; circadian syndrome; oxidative balance score; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A flow chart of participants screening in NHANES 2005–2018.
Figure 2
Figure 2
Subgroup analysis and interaction tests for the association between total OBS and CircS.
Figure 3
Figure 3
The RCS analysis of OBS and CircS. (A) a linear negative correlation between dietary OBS and CircS. (B) a non-linear negative correlation between lifestyle OBS and CircS. (C) a linear negative correlation between total OBS and CircS.
See this image and copyright information in PMC

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