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. 2024 Oct 21:17:7543-7550.
doi: 10.2147/JIR.S479310. eCollection 2024.

The Relationship Between Soluble Interleukin-17 Receptor Levels and CD3-Positive T Cells and Lymphocytes in Patients with Sepsis and Their Predictive Clinical Significance

Guixian Li  1 , Wenbo Zhang  2 , Wei Gu  2
Affiliations

The Relationship Between Soluble Interleukin-17 Receptor Levels and CD3-Positive T Cells and Lymphocytes in Patients with Sepsis and Their Predictive Clinical Significance

Guixian Li et al. J Inflamm Res. .

Abstract

Background: To assess the relationship between soluble interleukin-17 receptor (sIL-7R) levels and CD3-positive t cells and lymphocytes in patients with sepsis and their predictive clinical significance.

Methods: The study cohort comprised individuals diagnosed with sepsis based on the Third International Consensus Definitions for Sepsis and Septic Shock, treated in the emergency and critical care medicine departments at Beijing Chuiyangliu Hospital and Baoding No. 1 Central Hospital between December 2020 and June 2022. Patient outcomes were classified based on survival or mortality. Biomarkers, including sIL-7R levels and illness severity scores, were documented. All statistical analyses, including predictive modeling and comparisons were carried out using SPSS v.23.0 software and R software.

Results: On the fifth day post-admission, sIL-7R levels significantly decreased in both the survival and death groups, compared with levels on day one (2.09 ± 0.65 vs 1.07 ± 0.53 ng/mL, P < 0.01). There was a significant correlation between the sIL-7R level and the CD3+ T-lymphocyte count (CD3+) (r = 0.44) and lymphocyte count (LYM) (r = 0.42). The combination of the sIL-7R level with the Sequential Organ Failure Assessment (SOFA) score demonstrated optimal predictive value for clinical outcomes in patients with sepsis, demonstrated by an area under the receiver operating characteristic curve of 0.998.

Conclusion: sIL-7R levels are correlated with CD3+ and LYM counts. Additionally, the combination of serum sIL-7R level and SOFA score provides a robust method for predicting sepsis outcomes.

Keywords: immune function; prognosis; sepsis; soluble interleukin-7 receptor.

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Conflict of interest statement

Authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of sIL-7R levels between survival and death groups.
Figure 2
Figure 2
sIL-7R levels in survival and death groups on admission days 1 and 5.
Figure 3
Figure 3
Correlations of serum sIL-7R level with CD3+ and LYM on admission days 1 and 5. (A) Day 1; (B) day 5.
Figure 4
Figure 4
Internal validation of prognostic models (via bootstrapping) constructed using (A) sIL-7R level + SOFA score and (B) sIL-7R level + APACHE II score + SOFA score on admission day 5.
See this image and copyright information in PMC

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