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. 2024 Oct;21(10):1110-1119.
doi: 10.30773/pi.2024.0077. Epub 2024 Oct 17.

A Comparative Analysis of Neurocognitive Function in Community- and Hospital-Based Patients With Schizophrenia

Seri Maeng  1 , Hee Seon Kim  1 , Tae Joo Lee  2 , Hoon Jung Koo  3 , Won-Hyoung Kim  1
Affiliations

A Comparative Analysis of Neurocognitive Function in Community- and Hospital-Based Patients With Schizophrenia

Seri Maeng et al. Psychiatry Investig. 2024 Oct.

Abstract

Objective: The study compared differences in various neurocognitive characteristics across treatment modalities among schizophrenia patients recruited in one city between July 2020 and June 2023 who were on regular medication.

Methods: Of the 151 participants, 113 were included in the analysis. Participants were divided into community-based and hospital-based groups, and their demographics and clinical characteristics, including insight, quality of life, positive and negative symptoms, and personal and social functioning, were examined. In addition, several aspects of cognition were assessed using neurocognitive assessments such as the Trail Making Test (TMT), Stroop test, and Wisconsin Card Sorting Test (WCST). After adjusting for age differences between groups, the final analysis included data from 42 participants in the community-based group and 33 participants in the hospital-based group.

Results: Hospital-based group participants completed Stroop-W more rapidly, excelled in Rey-Osterrieth Complex Figure Test recall and recognition, and incurred fewer TMT Part B (TMT-B) and Stroop-C errors. Additionally, they outperformed in WCST total, non-persistent errors, and categories completed. Contrastingly, community-based group participants showed superior outcomes in WCST persistent responses and errors, suggesting specific neurocognitive strengths.

Conclusion: We found differences in neurocognitive characteristics between the two groups. These differences were consistent across a range of cognitive domains, including attention, visual discrimination, memory, and executive functioning. Further large-scale study is needed to generalize cognitive characteristics across treatment modalities.

Keywords: Cognitive test; Neurocognition; Schizophrenia.

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Conflict of interest statement

Conflicts of Interest

The authors have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flow diagram of participants’ recruitment.
See this image and copyright information in PMC

References

    1. Knapp M, Simon J, Percudani M, Almond S. In: Schizophrenia (2nd ed) Maj M, Sartorius N, editors. West Sussex: John Wiley & Sons Ltd; 2002. Economics of schizophrenia: a review; pp. 413–488.
    1. Norman RM, Malla AK, McLean T, Voruganti LP, Cortese L, McIntosh E, et al. The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale. Acta Psychiatr Scand. 2000;102:303–309. - PubMed
    1. Bruijnzeel D, Tandon R. The concept of schizophrenia: from the 1850s to the DSM-5. Psychiatr Ann. 2011;41:289–295.
    1. Kahn RS, Keefe RS. Schizophrenia is a cognitive illness: time for a change in focus. JAMA Psychiatry. 2013;70:1107–1112. - PubMed
    1. Bowie CR, Depp C, McGrath JA, Wolyniec P, Mausbach BT, Thornquist MH, et al. Prediction of real-world functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. Am J Psychiatry. 2010;167:1116–1124. - PMC - PubMed

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