Management of latent tuberculosis infection (LTBI) in adult patients with newly diagnosed acute leukemia: results of a survey among Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Fabio Forghieri¹, Francesca Bettelli², Simona Sgromo³, Gianpaolo Nadali⁴, Maria Ilaria Del Principe⁵, Elisa Buzzatti⁵, Francesca Farina⁶, Laura Cesini⁷, Antonio Giordano⁸, Marianna Criscuolo⁸, Davide Facchinelli⁹, Monica Piedimonte¹⁰, Chiara Sartor¹¹, Roberta De Marchi¹², Mario Delia¹³, Federico Mosna¹⁴, Laura Cudillo¹⁵, Giulia Tolomelli¹⁶, Claudia Maria Basilico¹⁷, Chiara Cattaneo¹⁸, Nicola Stefano Fracchiolla¹⁹, Federica Lessi²⁰, Olimpia Finizio²¹, Beatrice Anna Zannetti²², Adele Santoni²³, Paola Fazi²⁴, Francesco Marchesi³, Adriano Venditti⁵, Anna Candoni², Mario Luppi², Alessandro Busca²⁵, Livio Pagano^{8

26}

Affiliations

¹ Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Via del Pozzo 71, Modena, 41124, Italy. fabio.forghieri@unimore.it.
² Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Via del Pozzo 71, Modena, 41124, Italy.
³ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁴ Division of Hematology, Azienda Ospedaliera Universitaria Integrata, Policlinico GB Rossi, Verona, Italy.
⁵ Section of Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
⁶ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele (HSR), Milan, Italy.
⁷ Hematology Unit, S. Eugenio Hospital, ASL Roma, Rome, Italy.
⁸ Hematology Unit, Dipartimento Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
⁹ Hematology Unit, Ospedale San Bortolo, Vicenza, Italy.
¹⁰ Hematology Unit, "Sant'Andrea" Hospital-Sapienza, University of Rome, Rome, Italy.
¹¹ Division of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
¹² Onco Hematology, Department of Oncology, Veneto Institute of Oncology, Istituto Oncologico Veneto-Istituto di Ricerca e Cura a Carattere Scientifico (IOV-IRCCS), Castelfranco Veneto, Italy.
¹³ Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico-University of Bari, Bari, Italy.
¹⁴ Hematology and Bone Marrow Transplantation Unit (BMTU), Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsus Medical University (PMU), Bolzano, Italy.
¹⁵ Hematology Unit, San Giovanni Addolorata Hospital, Rome, Italy.
¹⁶ Unit of Hematology, Rimini Hospital "Infermi", Rimini, Italy.
¹⁷ Division of Hematology, ASST Sette Laghi, Ospedale Circolo e Fondazione Macchi, Varese, Italy.
¹⁸ Section of Hematology, Spedali Civili, Brescia, Italy.
¹⁹ Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁰ Hematology Unit, Department of Medicine - DIMED, University of Padova, Padua, Italy.
²¹ Division of Hematology, Cardarelli General Hospital, Naples, Italy.
²² Hematology Unit, Romagna Metropolitan Transplant Network - Hospital of Ravenna, University of Bologna, Ravenna, Italy.
²³ Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
²⁴ Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center, Rome, Italy.
²⁵ Department of Oncology, SSCVD Trapianto di Cellule Staminali, Città della Salute e della Scienza, Turin, Italy.
²⁶ Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 39465392
DOI: 10.1007/s00277-024-06047-6

Management of latent tuberculosis infection (LTBI) in adult patients with newly diagnosed acute leukemia: results of a survey among Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Fabio Forghieri et al. Ann Hematol. 2024 Dec.

. 2024 Dec;103(12):6045-6050.

doi: 10.1007/s00277-024-06047-6. Epub 2024 Oct 28.

Authors

Affiliations

¹ Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Via del Pozzo 71, Modena, 41124, Italy. fabio.forghieri@unimore.it.
² Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Via del Pozzo 71, Modena, 41124, Italy.
³ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁴ Division of Hematology, Azienda Ospedaliera Universitaria Integrata, Policlinico GB Rossi, Verona, Italy.
⁵ Section of Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
⁶ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele (HSR), Milan, Italy.
⁷ Hematology Unit, S. Eugenio Hospital, ASL Roma, Rome, Italy.
⁸ Hematology Unit, Dipartimento Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
⁹ Hematology Unit, Ospedale San Bortolo, Vicenza, Italy.
¹⁰ Hematology Unit, "Sant'Andrea" Hospital-Sapienza, University of Rome, Rome, Italy.
¹¹ Division of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
¹² Onco Hematology, Department of Oncology, Veneto Institute of Oncology, Istituto Oncologico Veneto-Istituto di Ricerca e Cura a Carattere Scientifico (IOV-IRCCS), Castelfranco Veneto, Italy.
¹³ Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico-University of Bari, Bari, Italy.
¹⁴ Hematology and Bone Marrow Transplantation Unit (BMTU), Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsus Medical University (PMU), Bolzano, Italy.
¹⁵ Hematology Unit, San Giovanni Addolorata Hospital, Rome, Italy.
¹⁶ Unit of Hematology, Rimini Hospital "Infermi", Rimini, Italy.
¹⁷ Division of Hematology, ASST Sette Laghi, Ospedale Circolo e Fondazione Macchi, Varese, Italy.
¹⁸ Section of Hematology, Spedali Civili, Brescia, Italy.
¹⁹ Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁰ Hematology Unit, Department of Medicine - DIMED, University of Padova, Padua, Italy.
²¹ Division of Hematology, Cardarelli General Hospital, Naples, Italy.
²² Hematology Unit, Romagna Metropolitan Transplant Network - Hospital of Ravenna, University of Bologna, Ravenna, Italy.
²³ Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
²⁴ Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center, Rome, Italy.
²⁵ Department of Oncology, SSCVD Trapianto di Cellule Staminali, Città della Salute e della Scienza, Turin, Italy.
²⁶ Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 39465392
DOI: 10.1007/s00277-024-06047-6

No abstract available

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no conflicts of interest to declare, relevant to this manuscript.

References

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1. Anibarro L, Pena A (2014) Tuberculosis in patients with Haematological Malignancies. Mediterr J Hematol Infect Dis 6:e2014026. https://doi.org/10.4084/MJHID.2014.026 - DOI - PubMed - PMC
1. Bergeron A (2021) Tuberculosis in allogeneic haematopoietic stem cell transplantation: so many unresolved questions! Bone Marrow Transpl 56(9):2050–2051. https://doi.org/10.1038/s41409-021-01381-z - DOI
1. Lee HJ, Lee DG, Choi SM, Park SH, Cho SY, Choi JK, Kim SH, Choi JH, Yoo JH, Cho BS, Eom KS, Lee S, Kim YJ, Kim HJ, Min CK, Kim DW, Lee JW, Min WS, Jung JI (2017) The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: high incidence compared with general population. PLoS ONE 12(3):e0173250. https://doi.org/10.1371/journal.pone.0173250 - DOI - PubMed - PMC
1. Cheng MP, Kusztos AE, Bold TD, Ho VT, Glotzbecker BE, Hsieh C, Baker MA, Baden LR, Hammond SP, Marty FM (2019) Risk of latent tuberculosis reactivation after hematopoietic-cell transplantation. Clin Infect Dis 69:869–872 - DOI - PubMed - PMC

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Management of latent tuberculosis infection (LTBI) in adult patients with newly diagnosed acute leukemia: results of a survey among Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Affiliations

Management of latent tuberculosis infection (LTBI) in adult patients with newly diagnosed acute leukemia: results of a survey among Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Authors

Affiliations

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources