Cobalt-catalyzed reductive cross-coupling: a review

Abstract

Transition-metal-catalyzed reductive cross-coupling is highly efficient for forming C-C bonds. It earns its limelight from its application by coupling unreactive electrophilic substrates to synthesize a variety of carbon-carbon bonds with various hybridizations (sp, sp², and sp³), late-stage functionalization, and bioactive molecules' synthesis. Reductive cross-coupling is challenging to bring selectivity but promising approach. Cobalt is comparatively more affordable than other highly efficient metals e.g., palladium and nickel but cobalt catalysis is still facing efficacy challenges. Researchers are trying to harness the maximum out of cobalt's catalytic properties. Shortly, with efficiency achieved combined with the affordability of cobalt, it will revolutionize industrial applications. This review gives insight into the core of cobalt-catalyzed reductive cross-coupling reactions with a variety of substrates forming a range of differently hybridized coupled products.

Keywords: Cobalt-catalyzed; C–C coupling; C–X coupling; Reductive cross-coupling; Transition-metal.