Aerobic or anaerobic? Microbial degradation of per- and polyfluoroalkyl substances: A review

Abstract

The widespread utilization of per- and polyfluoroalkyl substances (PFASs) as "forever chemicals" is posing significant environmental risks and adverse effects on human health. Microbial degradation (e.g., bacteria and fungi) has been identified as a cost-effective and environmentally friendly method for PFAS degradation. However, its degradation efficiency, biotransformation pathway, and microbial mechanism vary significantly under aerobic and anaerobic conditions. This review provides a comprehensive overview of the similarities and differences in PFAS microbial degradation by bacteria and fungi under different oxygen conditions. Initially, the efficiencies and metabolites of PFAS microbial degradation were compared under aerobic and anaerobic conditions, including perfluorinated and polyfluorinated compounds. Additionally, the microbial mechanisms of PFAS microbial degradation were obtained by summarizing key degrading microbes and enzymes. Finally, the comparisons between aerobic and anaerobic conditions in PFAS microbial degradation were provided, addressing the main challenges and proposing future research directions focused on seeking combined biodegradation techniques, exploring novel microbial species capable of degrading PFAS, and confirming complete biodegradation pathways. The understanding of PFAS microbial degradation in aerobic and anaerobic environments is crucial for providing potential solutions and future research efforts in dealing with these "forever chemicals".

Keywords: Aerobic biodegradation; Anaerobic biodegradation; Metabolic pathway; Microbial mechanism; Per- and polyfluoroalkyl substances (PFASs).