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. 2025 Feb;46(2):743-749.
doi: 10.1007/s10072-024-07809-w. Epub 2024 Oct 29.

Serum alpha klotho levels in Parkinson's Disease

Ahmet Yalcin  1 , Emine Gemci  2 , Busra Yurumez  2 , Rezzak Yilmaz  3   4 , Murat Varli  2 , Volkan Atmis  2 , M Cenk Akbostancı  3   4 , Nuray Yazihan  5
Affiliations

Serum alpha klotho levels in Parkinson's Disease

Ahmet Yalcin et al. Neurol Sci. 2025 Feb.

Abstract

Purpose: Parkinson's Disease (PD), a neurodegenerative disorder, is associated with substantial morbidity. α-Klotho, an anti-aging protein known for its neuroprotective properties, has gained attention. This study aims to assess serum levels of α-Klotho in PD patients.

Methods: This study is a cross-sectional case-control study. PD was diagnosed according to UK Parkinson Disease Society Brain Bank criteria. Serum α-Klotho level was measured using a commercially available enzyme-linked immunosorbent assay.

Results: Of the 314 participants in the study, 157 were patients with PD and 157 were controls. Lower levels of α-Klotho were observed in PD (0.85 nmol/L) in comparison to the controls (1.47 nmol/L, p < 0.001). α-Klotho levels were also significantly lower among PD patients with dementia compared to PD patients without dementia. In logistic regression analysis, α-Klotho (OR: 0.04, p < 0.001) demonstrated a significant relationship between PD. A significant correlation was identified between α-Klotho levels and Mini-Mental State Examination scores in PD patients. The sensitivity and the specifity of α-Klotho were 90% and 65% for predicting PD.

Conclusions: Our findings suggest that α-klotho could potentially serve as a biomarker. However additional studies are needed to confirm our findings.

Keywords: Dementia; Older individuals; Parkinson’s disease; α-Klotho protein.

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Conflict of interest statement

Declarations. Declaration of Generative AI and AI-assisted technologies in the writing process: During the preparation of this work the author(s) used Bard/Google Services in order to grammer checking. After using this tool, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. Competing interests: There is no conflict of interest among authors.

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