Topiramate and Metformin: Initial Insights into PCOS Weight Management and the Need for Further Research

Mina Amiri¹, Ricardo Azziz^{1

2

3

4

5}

Affiliations

¹ Foundation for Research and Education Excellence, Vestavia, AL 35243, USA.
² Department of Ob/Gyn, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL 35249, USA.
³ Department of Medicine, Heersink School of Medicine, UAB, Birmingham, AL 35249, USA.
⁴ Department of Healthcare Organization & Policy, School of Public Health, UAB, Birmingham, AL 35249, USA.
⁵ Department of Health Policy, Management, and Behavior, School of Public Health, University at Albany, SUNY, Rensselaer, NY 12144, USA.

Editorial

Mina Amiri et al. J Clin Endocrinol Metab. 2025.

. 2025 Aug 7;110(9):e3163-e3164.

doi: 10.1210/clinem/dgae752.

Mina Amiri¹, Ricardo Azziz^{1

2

3

4

5}

¹ Foundation for Research and Education Excellence, Vestavia, AL 35243, USA.
² Department of Ob/Gyn, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL 35249, USA.
³ Department of Medicine, Heersink School of Medicine, UAB, Birmingham, AL 35249, USA.
⁴ Department of Healthcare Organization & Policy, School of Public Health, UAB, Birmingham, AL 35249, USA.
⁵ Department of Health Policy, Management, and Behavior, School of Public Health, University at Albany, SUNY, Rensselaer, NY 12144, USA.

No abstract available

Keywords: diet; metformin; obesity; polycystic ovary syndrome; topiramate; weight loss.

Comment on

Topiramate Added to Metformin for Obesity Control in Women With Polycystic Ovary Syndrome.
Marchesan LB, da Silva TR, Spritzer PM. Marchesan LB, et al. J Clin Endocrinol Metab. 2025 May 19;110(6):e1892-e1901. doi: 10.1210/clinem/dgae637. J Clin Endocrinol Metab. 2025. PMID: 39271474 Clinical Trial.