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Review
. 2024 Jan-Dec;16(1):2415487.
doi: 10.1080/19490976.2024.2415487. Epub 2024 Oct 29.

A gut feeling of statin

Jianqing She  1   2   3 , Lizhe Sun  1   2 , Yue Yu  1   2 , Heze Fan  1   2 , Xia Li  1   2 , Xinyu Zhang  1   2 , Xiaozhen Zhuo  1   2   3 , Manyun Guo  1   2 , Junhui Liu  4 , Peining Liu  1   2 , Gulinigaer Tuerhongjiang  1   2 , Bin Du  1   2 , Hongbing Li  1   2 , Jun Yu  5 , Zuyi Yuan  1   2 , Yue Wu  1   2   3
Affiliations
Review

A gut feeling of statin

Jianqing She et al. Gut Microbes. 2024 Jan-Dec.

Abstract

Statins, known as HMG-CoA reductase inhibitors, are widely utilized to reduce blood cholesterol levels and possess pleiotropic effects, including the influence on inflammation and macrophage proliferation. Despite their significant impact in diminishing the incidence of cardiovascular events and mortality, individual responses to statin therapy vary considerably. Understanding this variability is essential for optimizing treatment outcomes and minimizing adverse effects. The gut microbiota, a complex ecosystem of microorganisms within the gastrointestinal tract, plays a critical role in human health and disease. Emerging evidence has linked the gut microbiota to drug metabolism and response, with the potential to modulate the efficacy of statin therapy and its side effects. This review provides a comprehensive overview of the interaction between the gut microbiota and statins. It discusses how the gut microbiota can influence the therapeutic effects and side effects of statins and examines the mechanisms by which the gut microbiota affect statin response and cardiovascular diseases.

Keywords: Statins; cardiovascular health; drug metabolism; gut microbiota; personalized treatment.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
The overview of statins in gut microbiota.
Figure 2.
Figure 2.
The mechanisms involved in statin metabolism. Statins influenced the FXR-SHP, FGF15, and PXR pathway.
Figure 3.
Figure 3.
Efficacy and adverse effects of gut microbiota-mediated statins.
See this image and copyright information in PMC

References

    1. Tajbakhsh A, Gheibihayat SM, Askari H, Savardashtaki A, Pirro M, Johnston TP, Sahebkar A.. Statin-regulated phagocytosis and efferocytosis in physiological and pathological conditions. Pharmacol Ther. 2022;238:108282. doi:10.1016/j.pharmthera.2022.108282. - DOI - PubMed
    1. Gasbarrino K, Hafiane A, Zheng H, Daskalopoulou SS. Intensive statin therapy compromises the Adiponectin-AdipoR pathway in the human monocyte-macrophage lineage. Stroke. 2019;50(12):3609–16. doi:10.1161/STROKEAHA.119.026280. - DOI - PubMed
    1. Ridker PM, Bhatt DL, Pradhan AD, Glynn RJ, MacFadyen JG, Nissen SE. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401(10384):1293–1301. doi:10.1016/S0140-6736(23)00215-5. - DOI - PubMed
    1. Bonsu KO, Reidpath DD, Kadirvelu A. Effects of statin treatment on inflammation and cardiac function in heart failure: an adjusted indirect comparison meta-analysis of randomized trials. Cardiovasc Ther. 2015;33(6):338–346. doi:10.1111/1755-5922.12150. - DOI - PubMed
    1. Adhyaru BB, Jacobson TA. Safety and efficacy of statin therapy. Nat Rev Cardiol. 2018;15(12):757–769. doi:10.1038/s41569-018-0098-5. - DOI - PubMed

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