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Editorial
. 2025 Apr;72(4):346-348.
doi: 10.1165/rcmb.2024-0445ED.

Cracking the Code of the Jugular Vagal Sensory Neurons in Allergic Airway Responsiveness

Aung Aung Kywe Moe  1   2
Affiliations
Editorial

Cracking the Code of the Jugular Vagal Sensory Neurons in Allergic Airway Responsiveness

Aung Aung Kywe Moe. Am J Respir Cell Mol Biol. 2025 Apr.
No abstract available

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Figures

Figure 1.
Figure 1.
A schematic diagram of airway innervation by the vagal sensory neurons and the pre- and postganglionic parasympathetic neurons. MrgprC11-positive jugular vagal sensory neurons innervate the airways and mediate allergen-induced airway hyperresponsiveness (6). The mechanistic link between MrgprC11 jugular neuronal activity and airway smooth muscle contraction mediated by acetylcholine acting on the muscarinic receptors is not yet understood. Further mechanistic insight can be achieved through examination of 1) the central termination sites of MrgprC11-positive jugular neurons and their influence on the activity of neurons in the nTS and preganglionic parasympathetic neurons in the DMNV and the NA and 2) the action of peripheral MrgprC11-positive terminals on the airway smooth muscles and the postganglionic neurons. DMNV = dorsal motor nucleus of the vagus; NA = nucleus ambiguous; nTS = nucleus of solitary tract; Pa5 = paratrigeminal nucleus.
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References

    1. Mazzone SB, Undem BJ. Vagal afferent innervation of the airways in health and disease. Physiol Rev . 2016;96:975–1024. - PMC - PubMed
    1. Prescott SL, Liberles SD. Internal senses of the vagus nerve. Neuron . 2022;110:579–599. - PMC - PubMed
    1. Pincus AB, Fryer AD, Jacoby DB. Mini review: neural mechanisms underlying airway hyperresponsiveness. Neurosci Lett . 2021;751:135795. - PMC - PubMed
    1. Tränkner D, Hahne N, Sugino K, Hoon MA, Zuker C. Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. Proc Natl Acad Sci U S A . 2014;111:11515–11520. - PMC - PubMed
    1. Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, et al. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness. Nat Neurosci . 2018;21:324–328. - PMC - PubMed

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