Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jan 14;134(1):386-92.
doi: 10.1016/0006-291x(86)90575-9.

Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes

L D Sutton, J S Stout, L Hosie, P S Spencer, D M Quinn

Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes

L D Sutton et al. Biochem Biophys Res Commun. .

Abstract

The cholesterol esterase and lipoprotein lipase catalyzed hydrolyses of the water-soluble substrate p-nitrophenyl butyrate are competitively inhibited by butaneboronic acid and phenylboronic acid. Phenyl-n-butylborinic acid has been synthesized and characterized as an ultrapotent transition state analog inhibitor: Ki = 2.9 +/- 0.6 nM and 1.7 +/- 0.3 microM for the cholesterol esterase and lipoprotein lipase reactions, respectively. These results are interpreted in terms of transition state structure and stabilization.

PubMed Disclaimer

Publication types

LinkOut - more resources