The Interplay of Inflammatory Bowel Disease (IBD) and Diabetes in Pediatrics: A Systematic Review

Abstract

The main objective of this study is to provide insights into the clinical problems and considerations in managing pediatric patients with both diabetes and inflammatory bowel disease (IBD) by summarizing the available information. We conducted a comprehensive search across electronic resources, including ScienceDirect, PubMed, Cochrane Library, and Scopus. Two independent reviewers evaluated and retrieved information from qualifying papers. Our data consists of five studies with 79,878 patients, 38225 (47.9%) of whom were female. Three studies included 2432 children diagnosed with IBD, and 17 (0.7%) were found with type 1 diabetes (T1D). Two studies comprised 77,446 children diagnosed with T1D and 83 (0.1%) had IBD. Children with immune-mediated diseases are more likely to have IBD, especially Crohn's disease. The included studies found no connection between T1D and childhood IBD. The important but little-known connection between diabetes and IBD in pediatric populations is brought to light by this comprehensive study. We were unable to discover a connection between pediatric IBD and DM. The review does, however, point out significant gaps in the literature, highlighting the need for more studies to comprehend the intricate interactions between these disorders and to create practical management plans for impacted children.

Keywords: children; crohn’s disease; diabetes mellitus; inflammatory bowel disease; systematic review; ulcerative colitis.

Figure 1. Study's decision-making is summarized in a PRISMA diagram.

PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses