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. 2024 Oct 29;11(10):ofae593.
doi: 10.1093/ofid/ofae593. eCollection 2024 Oct.

Lyme Disease Prophylaxis by Single-Dose Doxycycline in the United States, 2010-2020

Grace E Marx  1 , Alyssa Beck  2 , Cate Corey  3 , Candace C Fuller  4 , Nicole Haug  3 , Jenice S Ko  4 , Dave Martin  5 , Alison F Hinckley  1
Affiliations

Lyme Disease Prophylaxis by Single-Dose Doxycycline in the United States, 2010-2020

Grace E Marx et al. Open Forum Infect Dis. .

Abstract

Single-dose doxycycline after high-risk tick bites can prevent Lyme disease, which disproportionately affects children. We described single-dose doxycycline dispensings in an outpatient cohort in the United States. During 2010-2020, a total of 427 105 patients received ≥1 dispensing(s); most were aged ≥65 years. Lyme disease postexposure prophylaxis may be underprescribed for some groups, including children.

Keywords: Lyme disease; PEP; doxycycline; postexposure prophylaxis; tick bite.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest.

References

    1. Kugeler KJ, Schwartz AM, Delorey MJ, Mead PS, Hinckley AF. Estimating the frequency of Lyme disease diagnoses, United States, 2010–2018. Emerg Infect Dis 2021; 27:616–9. - PMC - PubMed
    1. Schwartz AM, Hinckley AF, Mead PS, Hook SA, Kugeler KJ. Surveillance for Lyme disease—United States, 2008–2015. MMWR Surveill Summ 2017; 66:1–12. - PMC - PubMed
    1. Kache PA, Bron GM, Zapata-Ramirez S, et al. Evaluating spatial and temporal patterns of tick exposure in the United States using community science data submitted through a smartphone application. Ticks Tick Borne Dis 2023; 14:102163. - PubMed
    1. Burtis JC, Bjork J, Johnson TL, Schiffman E, Neitzel D, Eisen RJ. Seasonal activity patterns of host-seeking Ixodes scapularis (Acari: Ixodidae) in Minnesota, 2015–2017. J Med Entomol 2023; 60:769–77. - PMC - PubMed
    1. Hinckley AF, Meek JI, Ray JAE, et al. Effectiveness of residential acaricides to prevent lyme and other tick-borne diseases in humans. J Infect Dis 2016; 214:182–8. - PMC - PubMed