Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 28;12(10):E1206-E1213.
doi: 10.1055/a-2341-9026. eCollection 2024 Oct.

Colorectal tumor comorbidity is common in patients with duodenal tumors: Exploratory cross-sectional study

Mari Mizutani  1 , Motohiko Kato  2 , Kazuhiro Yamanoi  3 , Akiko Matsubara  4 , Atsushi Nakayama  5 , Kayoko Fukuhara  6 , Kentaro Iwata  7 , Kurato Miyazaki  7 , Teppei Masunaga  5 , Yoko Kubosawa  7 , Yukie Hayashi  8 , Yusaku Takatori  5 , Teppei Akimoto  5 , Noriko Matsuura  5 , Rieko Bessho  6 , Tomohisa Sujino  9 , Kaoru Takabayashi  9 , Hitoshi Ichikawa  6 , Kazuhiro Kashiwagi  6 , Hiromasa Takaishi  6 , Yasunori Sato  10 , Takanori Kanai  7 , Ryoji Kushima  4 , Naohisa Yahagi  5
Affiliations

Colorectal tumor comorbidity is common in patients with duodenal tumors: Exploratory cross-sectional study

Mari Mizutani et al. Endosc Int Open. .

Abstract

Background and study aims The duodenum and colorectum are target organs for familial colorectal adenomatous polyposis, however, the association of duodenal epithelial tumors (DETs) and colorectal tumors is still controversial. The aim of our study was to elucidate the association between DET and colorectal tumor. Patients and methods This was an exploratory cross-sectional study of patients with DETs treated by endoscopic resection at our hospital, between November 2018 and October 2022. Individuals who underwent colonoscopy as part of the health screening comprised the reference control group for comparison. In both groups, lesions suspected of being tumors were resected. The main outcome was the adenoma detection rate (ADR). Other outcomes were the detection rate for advanced neoplasia (AN) and risk factors for colorectal adenoma and AN, evaluated using univariate and multivariable analyses. Results Analyses were based on data from 163 individuals in the DET group and 177 in the control group. ADR was higher in the DET (63.2%) than in the control (23.6%) group ( P < 0.001). AN and invasive cancer rates were also significantly higher in the DET than in the control group (AN: 20.9% vs 3.4%, respectively, P < 0.001; invasive cancer: 3.1% vs 0%, respectively, P < 0.001). On logistic regression analysis, DET was found to be associated with a 5-fold increase in the detection rate of adenoma and 6-fold increase in AN detection. Conclusions The study revealed significant association between DET and high ADR and a higher frequency of AN and invasive cancer. Screening colonoscopy is suggested for patients with DETs.

Keywords: Colorectal cancer; Endoscopy Lower GI Tract; Endoscopy Small Bowel; Neoplasia; Polyps / adenomas / ....

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Relevant characteristics of the study sample before matching.
See this image and copyright information in PMC

References

    1. Yahagi N, Kato M, Ochiai Y et al.Outcomes of endoscopic resection for superficial duodenal epithelial neoplasia. Gastrointest Endosc. 2018;88:676–682. - PubMed
    1. Yamasaki Y, Uedo N, Takeuchi Y et al.Current status of endoscopic resection for superficial nonampullary duodenal epithelial tumors. Digestion. 2018;97:45–51. - PubMed
    1. Serrano PE, Grant RC, Berk TC et al.Progression and management of duodenal neoplasia in familial adenomatous polyposis: A cohort study. Ann Surg. 2015;261:1138–1144. - PubMed
    1. Murray MA, Zimmerman MJ, Ee HC. Sporadic duodenal adenoma is associated with colorectal neoplasia. Gut. 2004;53:261–265. - PMC - PubMed
    1. Ramsoekh D, van Leerdam ME, Dekker E et al.Sporadic duodenal adenoma and the association with colorectal neoplasia: a case-control study. Am J Gastroenterol. 2008;103:1505–1509. - PubMed