Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 27;16(10):1213-1215.
doi: 10.4254/wjh.v16.i10.1213.

Bioactive constituents and action mechanism of Xiaoyao San for treatment of non-alcoholic fatty liver disease

Xiao-Xia Qiu  1 , Zheng Li  2
Affiliations

Bioactive constituents and action mechanism of Xiaoyao San for treatment of non-alcoholic fatty liver disease

Xiao-Xia Qiu et al. World J Hepatol. .

Abstract

Xiaoyao San (XYS) is a classic Chinese medicine prescription. It is traditionally used to relieve syndrome of "liver stagnation and spleen deficiency", a common syndrome type in traditional Chinese medicine, through soothing liver, tonifying spleen, and nourishing blood. Correspondingly, XYS has long application in the treatment of depression, dyspepsia and liver diseases. Given the rising of cutting-edge researches on XYS, there's a significant need to diligently uncover the bioactive constituents and action mechanisms of XYS for treating non-alcoholic fatty liver disease accordingly.

Keywords: Bioactive constituents; Fibrosis; Mechanisms; Non-alcoholic fatty liver disease; Xiaoyao San.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

References

    1. Mei XL, Wu SY, Wu SL, Luo XL, Huang SX, Liu R, Qiang Z. Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism. World J Hepatol. 2024;16:1051–1066. - PMC - PubMed
    1. Zhao W, Ji C, Zheng J, Zhou S, Tian J, Han Y, Qin X. Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model. Chin Herb Med. 2024;16:132–142. - PMC - PubMed
    1. Qiu JJ, Liu Z, Zhao P, Wang XJ, Li YC, Sui H, Owusu L, Guo HS, Cai ZX. Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model. World J Gastroenterol. 2017;23:810–816. - PMC - PubMed
    1. Qin F, Huang J, Qiu X, Hu S, Huang X. Quality control of modified xiaoyao san through the determination of 22 active components by ultra-performance liquid chromatography. J AOAC Int. 2011;94:1778–1784. - PubMed
    1. Zhou Y, Ren Y, Ma Z, Jia G, Gao X, Zhang L, Qin X. Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry. J Ethnopharmacol. 2012;141:187–192. - PubMed

LinkOut - more resources