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. 2024 Nov 15;38(14):1982-1987.
doi: 10.1097/QAD.0000000000004008. Epub 2024 Oct 31.

Hepatic steatosis-insulin resistance and type 2 diabetes in people with HIV at diagnosis: effect of initial antiretroviral therapy

Maria Luisa Montes  1   2 , Carmen Busca  1   2 , Marta Rava  2   3 , José Ignacio Bernardino  1   2 , Antonio Rivero  2   4 , Luz Martín-Carbonero  1   2 , Esperanza Cañas-Ruano  2   5 , Sofia Ibarra Ugarte  6 , María José Galindo  7 , Alfonso Cabello  8 , Juan González-García  1   2 ; CoRIS
Affiliations

Hepatic steatosis-insulin resistance and type 2 diabetes in people with HIV at diagnosis: effect of initial antiretroviral therapy

Maria Luisa Montes et al. AIDS. .

Abstract

We evaluated the impact of hepatic steatosis-insulin resistance (HS-IR) and liver fibrosis (LF) on type 2 diabetes mellitus (DM2) using triglyceride-glucose (TyG) and Fibrosis-4 (FIB-4). The incidence of DM2 was 12.9 [95% confidence interval (CI), 16.9-9.7] and 9.8 (95% CI, 6.9-13.6) per 1000 person-years in HS-IR and LF. The prevalence of HS-IR was significantly lower at 12 and 24 months with TDF + (3TC or FTC) + RPV [hazard ratio (HR) 0.5 [95% CI, 0.3-0.8], P < 0.01 at 12 months; 0.6 [0.4-0.9], P = 0.01 at 24 months].

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