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. 2024 Dec;55(12):e321-e322.
doi: 10.1161/STROKEAHA.124.048953. Epub 2024 Oct 30.

Safety and Effectiveness of Intravenous Thrombolysis in Patients With CADASIL: A Multicenter Study

Chih-Hao Chen  1 , Satoshi Saito  2 , Yi-Chung Lee  3   4   5 , Joong-Goo Kim  6 , Yu-Wen Cheng  1 , Yi-Chu Liao #  3   4   5 , Jay Chol Choi #  6 , Masafumi Ihara #  2 , Sung-Chun Tang #  1
Affiliations

Safety and Effectiveness of Intravenous Thrombolysis in Patients With CADASIL: A Multicenter Study

Chih-Hao Chen et al. Stroke. 2024 Dec.
No abstract available

Keywords: cerebral small vessel disease; mutation; reperfusion; thrombolysis.

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Conflict of interest statement

None.

Figures

Figure.
Figure.
Overview of the 12 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) who received intravenous thrombolysis. A, Clinical information and imaging markers of cerebral small vessel diseases. B, On postthrombolysis brain magnetic resonance imaging, diffusion restriction lesions can be seen (yellow arrows or yellow circle) in 8 patients, and all are <2 cm in diameter. C, Severity of white matter hyperintensities shown on FLAIR imaging. CMB indicates cerebral microbleed; ICH, intracerebral hemorrhage; NIHSS, National Institutes of Health Stroke Scale; and WMH, white matter hyperintensity.
See this image and copyright information in PMC

References

    1. Rutten JW, Dauwerse HG, Gravesteijn G, van Belzen MJ, van der Grond J, Polke JM, Bernal-Quiros M, Lesnik Oberstein SA. Archetypal notch3 mutations frequent in public exome: implications for cadasil. Ann Clin Transl Neurol. 2016;3:844–853. doi: 10.1002/acn3.344 - PMC - PubMed
    1. Dichgans M, Holtmannspotter M, Herzog J, Peters N, Bergmann M, Yousry TA. Cerebral microbleeds in cadasil: a gradient-echo magnetic resonance imaging and autopsy study. Stroke. 2002;33:67–71. doi: 10.1161/hs0102.100885 - PubMed
    1. Meschia JF, Worrall BB, Elahi FM, Ross OA, Wang MM, Goldstein ED, Rost NS, Majersik JJ, Gutierrez J; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Hypertension. Management of inherited cns small vessel diseases: the cadasil example: a scientific statement from the american heart association. Stroke. 2023;54:e452–e464. doi: 10.1161/STR.0000000000000444 - PubMed
    1. Mancuso M, Arnold M, Bersano A, Burlina A, Chabriat H, Debette S, Enzinger C, Federico A, Filla A, Finsterer J, et al. . Monogenic cerebral small-vessel diseases: diagnosis and therapy. Consensus recommendations of the european academy of neurology. Eur J Neurol. 2020;27:909–927. doi: 10.1111/ene.14183 - PubMed
    1. Pescini F, Torricelli S, Squitieri M, Giacomucci G, Poggesi A, Puca E, Bianchi S, Ragno M, Pantoni L. Intravenous thrombolysis in cadasil: report of two cases and a systematic review. Neurol Sci. 2023;44:491–498. doi: 10.1007/s10072-022-06449-2 - PMC - PubMed

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