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Case Reports
. 1986 Jan;21(1):71-4.
doi: 10.1111/j.1365-2125.1986.tb02824.x.

Relationship between plasma concentrations of clonidine and mean arterial pressure during an accidental clonidine overdose

L E Domino, S E Domino, M S Stockstill
Case Reports

Relationship between plasma concentrations of clonidine and mean arterial pressure during an accidental clonidine overdose

L E Domino et al. Br J Clin Pharmacol. 1986 Jan.

Abstract

The time course of toxicity in a 28 year old man following a 100 mg accidental overdose of clonidine hydrochloride is compared with the decline of plasma clonidine over 5 days. The concentration data were analyzed by nonlinear least squares regression, and fitted to a model which dissociated the blood pressure effects into pressor and depressor components. According to this analysis, there appeared to be two phases of toxicity over time--a hypertensive, and a hypotensive phase. The hypotensive and the hypertensive phases may result primarily through differential stimulation of central alpha 2-, alpha 1-, and vascular post-synaptic alpha 2-adrenoceptors as plasma concentrations fall.

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References

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