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. 2024 Nov 6;39(5):ivae179.
doi: 10.1093/icvts/ivae179.

The prognostic significance of modified frailty index-5 in patients undergoing pneumonectomy for lung cancer

Muhammet Sayan  1 , Bengisu Artiran  1 , Funda Ozturk  1 , Mahir Fattahov  1 , Irmak Akarsu  1 , Muhammet Tarik Aslan  1 , Gunel Ahmadova  1 , Aysegul Kurtoglu  1 , Ismail Cuneyt Kurul  1 , Ali Celik  1
Affiliations

The prognostic significance of modified frailty index-5 in patients undergoing pneumonectomy for lung cancer

Muhammet Sayan et al. Interdiscip Cardiovasc Thorac Surg. .

Abstract

Objectives: In some centrally located lung cancers, complete excision of the mass cannot be achieved with parenchymal-sparing procedures and pneumonectomy may be required. The mortality and morbidity rates of pneumonectomy were reported to be considerably high. Here, we investigated the effectivity of modified frailty index-5 (MFI-5) in patients undergoing pneumonectomy for non-small cell lung cancer.

Methods: Data of patients who underwent pneumonectomy for non-small cell lung cancer between January 2018 and December 2023 were reviewed retrospectively. The MFI-5 score was determined by preoperative diabetes mellitus, hypertension, chronic obstructive pulmonary diseases, congestive heart failure and functional status. The effectiveness of the MFI-5 score for the presence of postoperative major complications and 30-day mortality was investigated by multivariate logistic regression analysis. A P-value <0.05 was considered statistically significant.

Results: A total of 107 patients who met the inclusion criteria were included in the study. Eight (7.5%) of patients were female, and the mean age was 61.4 ± 8.7. The MFI-5 score was 0 in 48 patients (44.9%), 1 in 27 patients (25.2%) and 2 in 20 patients (18.7%). Postoperative 30-day mortality was detected in 4 patients (3.7%), and the major complications occurred in 42 patients (39.3%). In multivariate analysis, an MFI-5 score of 2 or higher (P = 0.008, OR: 4.9) was statistically significant for complications, whereas age, gender, side of the operation, <2 MFI-5 score, tumor diameter, type of surgery and lymph node metastasis status were not statistically significant (P > 0.05).

Conclusions: The MFI-5 score is a significant indicator for predicting major postoperative events in patients who underwent pneumonectomy for non-small cell lung cancer.

Clinical registration number: 2024-323, approved by Gazi University Local Ethics Committee.

Keywords: Lung cancer; Modified frailty index-5; Pneumonectomy; Prognosis.

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Figures

None
Graphical abstract
Figure 1:
Figure 1:
A CONSORT diagram of patient selection. NSCLC: non-small cell lung cancer.
Figure 2:
Figure 2:
The figure shows a significant correlation between high MFI-5 scores and postoperative complications. MFI-5: modified frailty index-5.
Figure 3:
Figure 3:
The figure shows the complication rates according to the MFI-5 score. MFI-5: modified frailty index-5.
See this image and copyright information in PMC

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