Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation: A Post Hoc Analysis of the MATTERHORN Trial

Felix Rudolph^#¹, Martin Geyer^#², Stephan Baldus³, Valeria Maria De Luca², Torsten Doenst⁴, Roman Pfister³, Jan Gummert⁵, Mirjam Kessler⁶, Peter Boekstegers⁷, Edith Lubos⁸, Jörg Schröder⁹, Holger Thiele¹⁰, Thomas Walther, Malte Kelm¹¹, Jörg Hausleiter¹², Ingo Eitel¹³, Ulrich Fischer-Rasokat¹⁴, Alexander Bufe¹⁵, Alexander Schmeisser¹⁶, Hüseyin Ince¹⁷, Philipp Lurz², Ralph Stephan von Bardeleben², Christian Hagl¹⁸, Thilo Noack¹⁹, Sebastian Reith²⁰, Harald Beucher⁷, Hermann Reichenspurner²¹, Wolfgang Rottbauer⁶, Paul Christian Schulze²², Wiebke Müller²³, Julia Frank²³, Claudia Michalik²⁴, Martin Hellmich²³, Thorsten Wahlers^{25

26}, Volker Rudolph¹, Christos Iliadis³

Affiliations

¹ Department of General and Interventional Cardiology/Angiology (F.R., V.R.), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Medical Faculty OWL, Bad Oeynhausen.
² Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, and the German Center for Cardiovascular Research Partner Site Rhine Main (M.G., V.M.D.L., P.L., R.S.v.B.).
³ University of Cologne, Faculty of Medicine and University Hospital Cologne, Department III for Internal Medicine, Cologne (S.B., R.P., C.I.).
⁴ Department of Cardiothoracic Surgery (T.D.), Jena University Hospital, Friedrich-Schiller-University of Jena.
⁵ Department of Thoracic and Cardiovascular Surgery (J.G.), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Medical Faculty OWL, Bad Oeynhausen.
⁶ Department of Cardiology, Ulm University Heart Center (M.K., W.R.).
⁷ Department of Cardiology, Helios Heart Center Siegburg (P.B., H.B.), University Witten/Herdecke.
⁸ Marienkrankenhaus, Department of Cardiology, University Hospital Eppendorf (E.L.).
⁹ Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University (J.S.).
¹⁰ Department of Cardiology (H.T.), Helios Heart Center Leipzig at Leipzig University, and Leipzig Heart Science.
¹¹ Department of Cardiology, University Hospital Düsseldorf and Cardiovascular Research Institute Düsseldorf (M.K.).
¹² Medical Clinic and Polyclinic I, Ludwig Maximilian University Munich, and the German Center for Cardiovascular Research (J.H.).
¹³ Medical Clinic II, University Heart Center Lübeck, and the German Center for Cardiovascular Research (I.E.).
¹⁴ Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim (U.F.-R.).
¹⁵ Department of Internal Medicine I, Helios Clinic Krefeld (A.B.), University Witten/Herdecke.
¹⁶ Department of Cardiology, Otto-von-Guericke-University Magdeburg (A.S.).
¹⁷ Department of Cardiology, University Medical Center Rostock (H.I.).
¹⁸ Department of Cardiac Surgery, Ludwig Maximilian University Munich (C.H.).
¹⁹ Department of Cardiac Surgery (T.N.), Helios Heart Center Leipzig at Leipzig University, and Leipzig Heart Science.
²⁰ Department of Cardiology, St. Franziskus Hospital, Münster (S.R.).
²¹ Department of Cardiothoracic Surgery, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (H.R.).
²² Department of Cardiology (P.C.S.), Jena University Hospital, Friedrich-Schiller-University of Jena.
²³ Institute of Medical Statistics and Computational Biology (W.M., J.F., M.H.), Faculty of Medicine and University Hospital Cologne, University of Cologne.
²⁴ Clinical Trials Centre Cologne (C.M.), Faculty of Medicine and University Hospital Cologne, University of Cologne.
²⁵ Department of Cardiovascular Surgery, University Hospital Frankfurt and Goethe University Frankfurt (T.W.).
²⁶ Department of Cardiothoracic Surgery (T.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne.

^# Contributed equally.

PMID: 39475706
DOI: 10.1161/CIRCULATIONAHA.124.072648

Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation: A Post Hoc Analysis of the MATTERHORN Trial

Felix Rudolph et al. Circulation. 2025.

. 2025 Feb 11;151(6):418-420.

doi: 10.1161/CIRCULATIONAHA.124.072648. Epub 2024 Oct 30.

Authors

Affiliations

¹ Department of General and Interventional Cardiology/Angiology (F.R., V.R.), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Medical Faculty OWL, Bad Oeynhausen.
² Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, and the German Center for Cardiovascular Research Partner Site Rhine Main (M.G., V.M.D.L., P.L., R.S.v.B.).
³ University of Cologne, Faculty of Medicine and University Hospital Cologne, Department III for Internal Medicine, Cologne (S.B., R.P., C.I.).
⁴ Department of Cardiothoracic Surgery (T.D.), Jena University Hospital, Friedrich-Schiller-University of Jena.
⁵ Department of Thoracic and Cardiovascular Surgery (J.G.), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Medical Faculty OWL, Bad Oeynhausen.
⁶ Department of Cardiology, Ulm University Heart Center (M.K., W.R.).
⁷ Department of Cardiology, Helios Heart Center Siegburg (P.B., H.B.), University Witten/Herdecke.
⁸ Marienkrankenhaus, Department of Cardiology, University Hospital Eppendorf (E.L.).
⁹ Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University (J.S.).
¹⁰ Department of Cardiology (H.T.), Helios Heart Center Leipzig at Leipzig University, and Leipzig Heart Science.
¹¹ Department of Cardiology, University Hospital Düsseldorf and Cardiovascular Research Institute Düsseldorf (M.K.).
¹² Medical Clinic and Polyclinic I, Ludwig Maximilian University Munich, and the German Center for Cardiovascular Research (J.H.).
¹³ Medical Clinic II, University Heart Center Lübeck, and the German Center for Cardiovascular Research (I.E.).
¹⁴ Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim (U.F.-R.).
¹⁵ Department of Internal Medicine I, Helios Clinic Krefeld (A.B.), University Witten/Herdecke.
¹⁶ Department of Cardiology, Otto-von-Guericke-University Magdeburg (A.S.).
¹⁷ Department of Cardiology, University Medical Center Rostock (H.I.).
¹⁸ Department of Cardiac Surgery, Ludwig Maximilian University Munich (C.H.).
¹⁹ Department of Cardiac Surgery (T.N.), Helios Heart Center Leipzig at Leipzig University, and Leipzig Heart Science.
²⁰ Department of Cardiology, St. Franziskus Hospital, Münster (S.R.).
²¹ Department of Cardiothoracic Surgery, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (H.R.).
²² Department of Cardiology (P.C.S.), Jena University Hospital, Friedrich-Schiller-University of Jena.
²³ Institute of Medical Statistics and Computational Biology (W.M., J.F., M.H.), Faculty of Medicine and University Hospital Cologne, University of Cologne.
²⁴ Clinical Trials Centre Cologne (C.M.), Faculty of Medicine and University Hospital Cologne, University of Cologne.
²⁵ Department of Cardiovascular Surgery, University Hospital Frankfurt and Goethe University Frankfurt (T.W.).
²⁶ Department of Cardiothoracic Surgery (T.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne.

^# Contributed equally.

PMID: 39475706
DOI: 10.1161/CIRCULATIONAHA.124.072648

No abstract available

Keywords: atrial functional mitral regurgitation; mitral regurgitation; randomized controlled trial; surgery; transcatheter edge-to-edge repair.

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Conflict of interest statement

S.B. reports an unrestricted research grant for the MATTERHORN trial from Abbott Vascular; an unrestricted research grant to perform a study in patients with heart failure receiving a myeloperoxidase inhibitor; and consultant honoraria from Edwards Lifesciences. R.P. reports the following: speaker engagement with Abbott Vascular and consultant for Edwards Lifesciences. M.K. reports a grant/contract from Abbott Vascular and Edwards Lifesciences. P.B. reports a consultant agreement for proctoring from Abbott Vascular. E.L. reports research funding from Abbott Vascular and Edwards Lifesciences; a grant/contract from Abbott Vascular and Edwards Lifesciences; speaker honoraria from Abbott, Abiomed, AstraZeneca, Bayer, Edwards Lifesciences, and Novartis; travel support from Abbott, Abiomed, AstraZeneca, Bayer, Cardiovalve, Edwards Lifesciences, Novartis, and New Valve Technology; and data safety monitoring board in New Valve Technology, Novartis, and Cardiovalve. J.G. reports the following: lecture fees from Abbott Vascular and Edwards Lifesciences, consultant as advisory board member in Berlin Heart, as selection committee in Fine Heart, and as advisory board member in Medtronic. M.K. reports grants/contracts from Abbott Vascular, Abiomed, Amgen, Braun Medical, Boston Scientific, Daiichi Sankzo Europe, Deutsche Forschungsgesellschaft, Edwards Lifesciences, Mars Scientific Advisory Council, Medtronic, Microvision, and Philips. J.H. reports consultant and travel fees from Edwards Lifesciences. A.S. reports speaker engagement with Abbott Vascular. H.I. is a consultant for Abbott Vascular. P.L. reports the following: consultant for Abbott Vascular, Boehringer Ingelheim, Edwards Lifesciences, Innoventric, Medtronic, ReCor; grant/contract from Boehringer Ingelheim and ReCor; stock option from Innoventric. R.S.B. reports the following: echocardiography core laboratory contract with University of Göttingen (RESHAPE-HF II trial) and echo corelab contract with University of Cologne (MATTERHORN trial); consulting fees from Abbott Vascular, Edwards Lifesciences, Jenscare, and Medtronic; honoraria from Abbott Vascular, Edwards Lifesciences, Jenavalve, Jenscare, Medtronic, Philips, and Siemens; data safety monitoring board member for Medtronic; and committee member of Heart Valve Society and European Union Structural Heart Disease Coalition. T.N. received grants/contracts from Abbott Vascular, Edwards Lifesciences, and Medtronic. H.R. reports lecture fees from Edwards Lifesciences. W.R. reports a consultant agreement from Abbott Vascular. P.C.S. reports data and safety monitoring for Abbott Vascular, AstraZeneca, and Bayer; grants/contracts from Abiomed, Boehringer Ingelheim, Bundeministerium für Bildung und Forschung, Deutsche Herzstiftung, Edwards Lifesciences, and Else-Kröner-Fresenius-Stiftung; and speaker engagement with Abiomed, Bayer, Boehringer Ingelheim, Daiichi Sankyo, Edwards Lifesciences, Medtronic, and Pharmacosmos Therapeutics. W.M. reports funding from the Department of Cardiology, University of Cologne, as payment to the Institute of Medical Statistics and Computational Biology, University of Cologne. M.H. reports employment with the University of Cologne. V.R. reports a grant/contract from Abbott Vascular and Edwards Lifesciences. C.I. reports travel expenses and consultant honoraria from Abbott Vascular and Edwards Lifesciences. The other authors report no conflicts.

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Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation: A Post Hoc Analysis of the MATTERHORN Trial

Affiliations

Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation: A Post Hoc Analysis of the MATTERHORN Trial

Authors

Affiliations

Conflict of interest statement

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