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Multicenter Study
. 2024 Nov-Dec;38(6):2712-2717.
doi: 10.21873/invivo.13749.

Real-world Referral Pattern of Unplanned Excision in Patients With Soft-tissue Sarcoma: A Multicenter Study Conducted by the Bone and Soft-tissue Tumor Study Group of the Japan Clinical Oncology Group

Tomoki Nakamura  1 , Koichi Ogura  2 , Keiko Hayakawa  3 , Kunihiro Ikuta  4 , Yutaka Nezu  5 , Shinji Miwa  6 , Shinichiro Yoshida  7 , Sho Nakai  8   9 , Hideyuki Kinoshita  10 , Yusuke Kawabata  11 , Shunsuke Hamada  12 , Akira Nabeshima  13 , Hidetatsu Outani  9 , Hiroshi Kobayashi  14 , Hitomi Hara  15 , Masanori Tsugita  16 , Hirotaka Koyanagi  17 , Nokitaka Setsu  18 , Akira Maekawa  19 , Akihiro Daisaku  20 , Tomoaki Mori  21 , Naoki Oike  22 , Yuta Kubota  23 , Takaaki Tanaka  24 , Takashi Noguchi  25 , Takashi Tajima  26 , Kazuhiro Tanaka  27 , Toshifumi Ozaki  28
Affiliations
Multicenter Study

Real-world Referral Pattern of Unplanned Excision in Patients With Soft-tissue Sarcoma: A Multicenter Study Conducted by the Bone and Soft-tissue Tumor Study Group of the Japan Clinical Oncology Group

Tomoki Nakamura et al. In Vivo. 2024 Nov-Dec.

Abstract

Background/aim: Despite the well-publicized clinical outcomes after unplanned excision (UE) and re-excision (re-excision) in patients with soft-tissue sarcoma (STS), there is little information about the real-life referral patterns for UE, such as patient profile, details of procedures, and subsequent management after UE. We aimed to investigate the characteristics of patients with UE who were referred to sarcoma-specific centers.

Patients and methods: Between May 2022 and June 2023, we registered 97 patients who underwent UE and were referred to sarcoma-specific centers in Japan. We excluded those with well-differentiated liposarcomas and dermatofibrosarcoma protuberances. We investigated the details of UE and additional treatment after UE.

Results: There were 49 men and 48 women, with a mean age of 62 years. A broad range of surgeons performed UE; 36 plastic surgeons, 22 orthopedic surgeons, 17 general surgeons, 17 dermatologists, and 5 others. The mean tumor size was 4.1 cm. Local anesthesia was administered to 58 patients. Forty-five patients underwent UE without prior magnetic resonance imaging. Inappropriate transverse skin incisions were performed in 42 patients. Of the 97 patients, 82 underwent re-excision after UE. The mean time between UE and date of initial presentation at the referral hospital was 46 days. The mean interval between UE and re-excision was 96 days. Of the 82 patients, 59 underwent soft-tissue reconstruction after re-excision.

Conclusion: A broad range of surgeons performed UE. Continuous education about STS should be considered for all surgeons. UE should be avoided because residual tumors are common, and reconstructive surgery may be necessary.

Keywords: Soft-tissue sarcoma; re-excision; unplanned excision.

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Conflict of interest statement

The Authors declare no conflicts of interest for this study.

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