Developing frameworks for nanotechnology-driven DNA-free plant genome-editing

Neelam Gogoi¹, Hendry Susila², Joan Leach³, Markus Müllner⁴, Brian Jones⁵, Barry J Pogson⁶

Affiliations

¹ ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia. Electronic address: neelam.gogoi@anu.edu.au.
² ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia.
³ ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia; Australian National Centre for the Public Awareness of Science, The Australian National University, Canberra, ACT 2601, Australia.
⁴ Key Centre for Polymers & Colloids, School of Chemistry, Faculty of Science, The University of Sydney, NSW 2006, Australia; Sydney Institute of Agriculture, The University of Sydney, NSW 2006, Australia; The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, NSW 2006, Australia.
⁵ Sydney Institute of Agriculture, The University of Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia.
⁶ ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia. Electronic address: barry.pogson@anu.edu.au.

PMID: 39477773
DOI: 10.1016/j.tplants.2024.09.014

Review

Developing frameworks for nanotechnology-driven DNA-free plant genome-editing

Neelam Gogoi et al. Trends Plant Sci. 2025 Mar.

. 2025 Mar;30(3):249-268.

doi: 10.1016/j.tplants.2024.09.014. Epub 2024 Oct 29.

Authors

Neelam Gogoi¹, Hendry Susila², Joan Leach³, Markus Müllner⁴, Brian Jones⁵, Barry J Pogson⁶

Affiliations

¹ ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia. Electronic address: neelam.gogoi@anu.edu.au.
² ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia.
³ ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia; Australian National Centre for the Public Awareness of Science, The Australian National University, Canberra, ACT 2601, Australia.
⁴ Key Centre for Polymers & Colloids, School of Chemistry, Faculty of Science, The University of Sydney, NSW 2006, Australia; Sydney Institute of Agriculture, The University of Sydney, NSW 2006, Australia; The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, NSW 2006, Australia.
⁵ Sydney Institute of Agriculture, The University of Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia.
⁶ ARC Training Centre for Future Crops Development, Research School of Biology, College of Science, The Australian National University, Canberra, ACT 2601, Australia. Electronic address: barry.pogson@anu.edu.au.

PMID: 39477773
DOI: 10.1016/j.tplants.2024.09.014

Abstract

The bottlenecks of conventional plant genome-editing methods gave an innovative rise to nanotechnology as a delivery tool to manipulate gene(s) of interest. Studies suggest a strong correlation between the physicochemical properties of nanomaterials and their efficiency in gene delivery to different plant species/tissues. In this opinion article we highlight the need for a deeper understanding of plant-nanomaterial interactions to align their full capabilities with the strategic goals of plant genome-editing. Additionally, we emphasize DNA-free plant genome-editing approaches to potentially mitigate concerns surrounding genetically modified organisms (GMOs). Lastly, we propose a strategic integration of the principles of responsible research and innovation (RRI) in R&D. We aim to initiate a dialogue on developing collaborative and socio-technical frameworks for nanotechnology and DNA-free plant genome-editing.

Keywords: CRISPR/Cas; DNA-free; RRI; nanotechnology.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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Developing frameworks for nanotechnology-driven DNA-free plant genome-editing

Affiliations

Developing frameworks for nanotechnology-driven DNA-free plant genome-editing

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources