The medial frontal cortex and gastric motility: microstimulation results and their possible significance for the overall pattern of organization of rat frontal and parietal cortex

Abstract

Bilateral intracortical microstimulation (60-90 strains of 0.5 ms pulses at 10 Hz, currents below 50 microA) of medial frontal infralimbic and prelimbic cortical areas in ketamine-anesthetized rats produces clear and consistent decreases in ongoing gastric motility. The majority of responses consists of reductions in gastric tone, reductions in the amplitude of gastric contractions, or combined reductions in tone and amplitude. Bilateral section of the vagus nerves eliminates most of the responses, suggesting that the responses are mediated by this nerve. The effective cortical stimulation zone (the 'visceral motor' cortex) largely overlaps the source of the recently described direct projection from medial frontal cortex to the nucleus of the solitary tract; this pathway may be involved in producing the effect. Connections of this cortex with the limbic system suggest it may be involved in producing physiological responses to stress. The topographical, medial to lateral sequence of cortical functional areas revealed by these and other experiments (visceral motor, frontal eye fields, somatic motor, somatic sensory, visceral sensory) is discussed, as well as the possible implications of this pattern to the question of cortical evolutionary development.