Metabolic Brain PET Connectivity

Tatiana Horowitz¹, Matthieu Doyen², Silvia Paola Caminiti³, Igor Yakushev⁴, Antoine Verger⁵, Eric Guedj⁶

Affiliations

¹ Aix Marseille Univ, Marseille, France; CERIMED, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France; Nuclear Medicine Department, AP-HM, Timone Hospital, Marseille, France. Electronic address: Tatiana.horowitz@univ-amu.fr.
² University of Lorraine, IADI, INSERM U1254, Nancy, France.
³ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
⁴ Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
⁵ Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy, France.
⁶ Aix Marseille Univ, Marseille, France; CERIMED, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France; Nuclear Medicine Department, AP-HM, Timone Hospital, Marseille, France.

PMID: 39482220
DOI: 10.1016/j.cpet.2024.09.014

Review

Metabolic Brain PET Connectivity

Tatiana Horowitz et al. PET Clin. 2025 Jan.

. 2025 Jan;20(1):1-10.

doi: 10.1016/j.cpet.2024.09.014. Epub 2024 Oct 30.

Authors

Tatiana Horowitz¹, Matthieu Doyen², Silvia Paola Caminiti³, Igor Yakushev⁴, Antoine Verger⁵, Eric Guedj⁶

Affiliations

¹ Aix Marseille Univ, Marseille, France; CERIMED, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France; Nuclear Medicine Department, AP-HM, Timone Hospital, Marseille, France. Electronic address: Tatiana.horowitz@univ-amu.fr.
² University of Lorraine, IADI, INSERM U1254, Nancy, France.
³ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
⁴ Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
⁵ Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, Nancy, France.
⁶ Aix Marseille Univ, Marseille, France; CERIMED, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France; Nuclear Medicine Department, AP-HM, Timone Hospital, Marseille, France.

PMID: 39482220
DOI: 10.1016/j.cpet.2024.09.014

Abstract

This review examines the role of metabolic connectivity based on fluorodeoxyglucose-PET in understanding brain network organization across neurologic disorders, with a focus on neurodegenerative diseases. The article explores key methodologies for metabolic connectivity study and highlights altered connectivity patterns in Alzheimer's, Parkinson's, frontotemporal dementia, and other conditions. It also discusses emerging applications, including single-subject analyses and brain-organ interactions.

Keywords: Brain connectivity; FDG; Fluorodeoxyglucose; Metabolic connectivity; Neuroimaging; PET.

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Conflict of interest statement

Disclosure TH, EG, MD, AV have nothing to disclose. SPC is supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) – A multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022). IY has Consultant fees from ABX-CRO, Blue Earth Diagnostics, and Pentixapharm, and speaker honoraria from Piramal; and funding from Alzheimer Research Initiative Germany - Federal Ministry of Education and Research Germany (BMBF) - German Research Foundation (DFG).

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Metabolic Brain PET Connectivity

Affiliations

Metabolic Brain PET Connectivity

Authors

Affiliations

Abstract

Conflict of interest statement

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