Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype

Boyi Zhang¹, Qilai Long², Shanshan Wu¹, Qixia Xu³, Shuling Song¹, Liu Han¹, Min Qian¹, Xiaohui Ren¹, Hanxin Liu⁴, Jing Jiang⁴, Jianming Guo², Xiaoling Zhang⁵, Xing Chang⁶, Qiang Fu⁷, Eric W-F Lam⁸, Judith Campisi^{9

10}, James L Kirkland¹¹, Yu Sun^{12

13

14

15}

Affiliations

¹ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
² Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
³ Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
⁴ Department of Pharmacology, Binzhou Medical University, Yantai, China.
⁵ Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
⁷ Department of Pharmacology, Binzhou Medical University, Yantai, China. qiangfu11@fudan.edu.cn.
⁸ Department of Surgery and Cancer, Imperial College London, London, UK.
⁹ Buck Institute for Research on Aging, Novato, CA, USA.
¹⁰ Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
¹¹ Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
¹² CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. sunyu@sibs.ac.cn.
¹³ Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. sunyu@sibs.ac.cn.
¹⁴ Department of Pharmacology, Binzhou Medical University, Yantai, China. sunyu@sibs.ac.cn.
¹⁵ Department of Medicine and VAPSHCS, University of Washington, Seattle, WA, USA. sunyu@sibs.ac.cn.

PMID: 39482439
DOI: 10.1038/s43587-024-00749-2

Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype

Boyi Zhang et al. Nat Aging. 2024 Dec.

. 2024 Dec;4(12):1898.

doi: 10.1038/s43587-024-00749-2.

Authors

Affiliations

¹ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
² Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
³ Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
⁴ Department of Pharmacology, Binzhou Medical University, Yantai, China.
⁵ Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
⁷ Department of Pharmacology, Binzhou Medical University, Yantai, China. qiangfu11@fudan.edu.cn.
⁸ Department of Surgery and Cancer, Imperial College London, London, UK.
⁹ Buck Institute for Research on Aging, Novato, CA, USA.
¹⁰ Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
¹¹ Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
¹² CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. sunyu@sibs.ac.cn.
¹³ Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. sunyu@sibs.ac.cn.
¹⁴ Department of Pharmacology, Binzhou Medical University, Yantai, China. sunyu@sibs.ac.cn.
¹⁵ Department of Medicine and VAPSHCS, University of Washington, Seattle, WA, USA. sunyu@sibs.ac.cn.

PMID: 39482439
DOI: 10.1038/s43587-024-00749-2

No abstract available

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Retraction of

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype.
Zhang B, Long Q, Wu S, Xu Q, Song S, Han L, Qian M, Ren X, Liu H, Jiang J, Guo J, Zhang X, Chang X, Fu Q, Lam EW, Campisi J, Kirkland JL, Sun Y. Zhang B, et al. Nat Aging. 2021 May;1(5):454-472. doi: 10.1038/s43587-021-00063-1. Epub 2021 May 13. Nat Aging. 2021. Retraction in: Nat Aging. 2024 Dec;4(12):1898. doi: 10.1038/s43587-024-00749-2. PMID: 34263179 Free PMC article. Retracted.

References

1. Chen, F. et al. Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance. Nat. Commun. 9, 4315 (2018). - DOI - PubMed - PMC
1. Xu, Q. et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat. Metab. 3, 1706–1726 (2021). - DOI - PubMed - PMC

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Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype

Affiliations

Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype

Authors

Affiliations

Retraction of

References

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