Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 17:37:11872.
doi: 10.3389/ti.2024.11872. eCollection 2024.

Outcome of Solid Organ Transplantation in Patients With Intellectual Disability: A Systematic Literature Review

Ingeborg de Rover  1 , Lara Orlandini  1 , Sarwa Darwish Murad  2 , Wojciech G Polak  1 , Jane Hartley  3 , Khalid Sharif  3 , Dimitri Sneiders  1 , Hermien Hartog  1   3   4
Affiliations

Outcome of Solid Organ Transplantation in Patients With Intellectual Disability: A Systematic Literature Review

Ingeborg de Rover et al. Transpl Int. .

Abstract

Access to solid organ transplantation in patients with intellectual disability is associated with health inequities due to concerns about treatment adherence, survival rates, and post-transplant quality of life. This systematic literature review aims to compare outcomes after organ transplantation in patients with intellectual disability compared to patients without intellectual disability. Embase, Medline Ovid, PsycINFO, Web of Science, Cochrane Central Register of Trials, and Google Scholar databases were systematically searched for studies concerning pediatric or adult solid organ transplantation in recipients with a diagnosis of intellectual disability prior to transplantation. Primary outcomes were patient and graft survival rates. Secondary outcomes were acute rejection rate, adherence rates, and quality of life. Nine studies were included, describing kidney (n = 6), heart (n = 4) and liver (n = 1) transplantation. Reported graft survival rates were non-inferior or better compared to patients without intellectual disability, while patient survival was reportedly slightly lower in two studies reporting on kidney transplantation. Although current evidence has a potential selection bias based on including patients with a sufficient support network, intellectual disability alone should not be regarded a relative or absolute contra-indication for solid organ transplantation.

Keywords: adherence; graft survival; intellectual disability; organ transplantation; rejection.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
PRISMA flow chart.
FIGURE 2
FIGURE 2
Quality assessment of the individual studies.
See this image and copyright information in PMC

References

    1. Maulik PK, Mascarenhas MN, Mathers CD, Dua T, Saxena S. Prevalence of Intellectual Disability: A Meta-Analysis of Population-Based Studies. Res Dev Disabil (2011) 32(2):419–36. 10.1016/j.ridd.2010.12.018 - DOI - PubMed
    1. Association AP. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. (2013). Text Revision (DSM-5-TR).
    1. Hosking FJ, Carey IM, Shah SM, Harris T, DeWilde S, Beighton C, et al. Mortality Among Adults With Intellectual Disability in England: Comparisons With the General Population. Am J Public Health (2016) 106(8):1483–90. 10.2105/AJPH.2016.303240 - DOI - PMC - PubMed
    1. Albrecht GL, Devlieger PJ. The Disability Paradox: High Quality of Life against All Odds. Soc Sci Med (1999) 48(8):977–88. 10.1016/s0277-9536(98)00411-0 - DOI - PubMed
    1. Collins TL, Wayne Holden E, Scheel JN. Cognitive Functioning as a Contraindication to Organ Transplant Surgery: Dilemmas Encountered in Medical Decision Making. J Clin Psychol Med Settings (1996) 3(4):413–22. 10.1007/BF01994023 - DOI - PubMed

Publication types

LinkOut - more resources